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天冬氨酸转氨酶与血小板比值指数(APRI)评分在机器人辅助下进行的小型、技术上大型及大型肝肿瘤肝切除术后结局中的作用。

The role of the AST-to-platelet ratio index (APRI) score on outcomes following robotic minor, technically major, & major hepatectomy for liver tumors.

作者信息

Syblis Cameron, Christodoulou Maria, Ross Sharona, Pattilachan Tara Menon, Rosemurgy Alexander, Sucandy Iswanto

机构信息

University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Division Chief of Hepatopancreatobiliary Surgery, Digestive Health Institute, AdventHealth Tampa, 3000 Medical Park Drive, Suite # 500, Tampa, FL, 33613, USA.

出版信息

J Robot Surg. 2025 May 12;19(1):213. doi: 10.1007/s11701-025-02372-8.

Abstract

Predictive capability of aspartate transaminase-to-platelet ratio index (APRI) in assessing liver fibrosis/cirrhosis. This study aims to evaluate the correlation between APRI scores and perioperative outcomes following robotic hepatectomy. Data of 530 consecutive patients undergoing robotic hepatectomy were analyzed. Patients were classified based on an APRI score threshold of 0.7 and extent of resection. Data are presented as median (mean ± SD). Of 530 patients, 166 (31%) underwent major resection. Expectedly, major resections were associated with higher expert-level operations based on IWATE system. While having statistically similar APRI scores, patients undergoing major resection had larger tumor size (p = 0.003), longer operative duration (p < 0.0001), and higher blood loss (p = 0.0002). Patients undergoing minor/technically major resections, 100 (27%) patients had an elevated APRI, which was associated with higher MELD score (p = 0.0001), Child-Pugh score (p = 0.0001), cirrhosis (p < 0.0001), and neoplastic diseases (p < 0.0001). Patients undergoing major resections, 48 (29%) had elevated APRI, which was also associated with higher Child-Pugh Score (p < 0.0001), cirrhosis (p = 0.0008), and neoplastic diseases (p = 0.001). Elevated APRI levels were indicative of cirrhosis and higher MELD score; however, outcomes following robotic major hepatectomy remain unaffected by the index.

摘要

天冬氨酸转氨酶与血小板比值指数(APRI)在评估肝纤维化/肝硬化中的预测能力。本研究旨在评估APRI评分与机器人肝切除术后围手术期结局之间的相关性。分析了530例连续接受机器人肝切除术患者的数据。根据APRI评分阈值0.7和切除范围对患者进行分类。数据以中位数(均值±标准差)表示。在530例患者中,166例(31%)接受了大手术切除。不出所料,根据岩手系统,大手术切除与更高水平的专家级手术相关。虽然APRI评分在统计学上相似,但接受大手术切除的患者肿瘤更大(p = 0.003)、手术时间更长(p < 0.0001)、失血量更多(p = 0.0002)。接受小手术/技术上的大手术切除的患者中,100例(27%)APRI升高,这与更高的终末期肝病模型(MELD)评分(p = 0.0001)、Child-Pugh评分(p = 0.0001)、肝硬化(p < 0.0001)和肿瘤性疾病(p < 0.0001)相关。接受大手术切除的患者中,48例(29%)APRI升高,这也与更高的Child-Pugh评分(p < 0.0001)、肝硬化(p = 0.0008)和肿瘤性疾病(p = 0.001)相关。APRI水平升高表明存在肝硬化和更高的MELD评分;然而,机器人肝大切除术后的结局不受该指数的影响。

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