Tan Dong, Yang Xin, Yang Jing, Fan Gang, Xiong Guozuo
Department of Vascular Surgery, the Second Affiliated Hospital of University of South China, Hengyang, Hunan, China.
Pan-Vascular Research Group, Shenzhen University Affiliated Sixth Hospital, Shenzhen, Guangdong, China.
Aging Dis. 2025 Apr 18. doi: 10.14336/AD.2024.1713.
The aging process significantly contributes to human disease, and as worldwide life expectancy increases, addressing the challenges of aging and age-related cardiovascular diseases is becoming increasingly urgent. Vascular aging is a key link between aging and the development of age-related diseases. Recent studies indicate that proprotein convertase subtilisin/kexin type 9 (PCSK9), a type of protein involved in the metabolism of lipids, is crucial in modulating vascular aging by affecting the physiological functioning of vascular cells. PCSK9 is linked to lipid metabolism and chronic inflammation and is involved in regulating senescence-related activities, including migration, proliferation, apoptosis, and differentiation. These factors contribute to the aging of vascular cells and age-related vascular diseases, including atherosclerosis, hypertension, coronary artery disease, and cerebrovascular diseases. Given its involvement in these processes, this article provides a comprehensive summary of PCSK9's regulatory functions in vascular aging, highlighting potential therapeutic targets for combating age-related cardiovascular diseases.
衰老过程对人类疾病有显著影响，随着全球预期寿命的增加，应对衰老及与年龄相关的心血管疾病挑战变得愈发紧迫。血管老化是衰老与年龄相关疾病发展之间的关键环节。近期研究表明，前蛋白转化酶枯草溶菌素/克新9型（PCSK9），一种参与脂质代谢的蛋白质，通过影响血管细胞的生理功能在调节血管老化方面至关重要。PCSK9与脂质代谢和慢性炎症相关，并参与调节包括迁移、增殖、凋亡和分化在内的衰老相关活动。这些因素导致血管细胞衰老及与年龄相关的血管疾病，包括动脉粥样硬化、高血压、冠状动脉疾病和脑血管疾病。鉴于其参与这些过程，本文全面总结了PCSK9在血管老化中的调节功能，突出了对抗与年龄相关心血管疾病的潜在治疗靶点。
