Demetriades D
S Afr Med J. 1985 Aug 17;68(4):235-8.
In an experimental study the effect of cholecystectomy on bile reflux into the stomach was investigated. Five dogs were used and a large number of bile reflux measurements carried out (115 tests). During each test, reflux was measured over a continuous period of 6 hours by estimating the concentration of bile phospholipids (lecithin and lysolecithin) in the gastric juice. The pre-cholecystectomy phospholipid concentration in the stomach was 7,751 +/- 1,621 mg/dl (mean +/- SEM) and the post-cholecystectomy concentration 35,181 +/- 10,653 mg/dl (P less than 0,05). Two dogs developed gastric mucosal changes, mainly foveolar hyperplasia. The importance of measuring reflux repeatedly over long periods of time in order to get a more representative picture of reflux is stressed.
在一项实验研究中，对胆囊切除术对胆汁反流至胃的影响进行了调查。使用了5只狗，并进行了大量的胆汁反流测量（115次测试）。在每次测试中，通过估计胃液中胆汁磷脂（卵磷脂和溶血卵磷脂）的浓度，在连续6小时的时间段内测量反流情况。胆囊切除术前胃内磷脂浓度为7,751±1,621毫克/分升（平均值±标准误），胆囊切除术后浓度为35,181±10,653毫克/分升（P<0.05）。两只狗出现了胃黏膜变化，主要是小凹增生。强调了为了获得更具代表性的反流情况而长时间反复测量反流的重要性。
