Ranjbar Mahsa, Shab-Bidar Sakineh, Rostamian Abdolrahman, Mohammadi Hamed, Tavakoli Aryan, Djafarian Kurosh
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Neuroscience Institute, Sports Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Complement Ther Med. 2025 Aug;91:103189. doi: 10.1016/j.ctim.2025.103189. Epub 2025 May 10.
Rheumatoid arthritis (RA), in the category of rheumatic diseases, is an autoimmune illness that affects joints and other parts of suffered patients. Intermittent fasting (IF) is a dietary pattern that has had beneficial impacts on several populations. This randomized controlled trial (RCT) hypothesized that IF can improve quality of life, clinical symptoms, inflammation, and oxidative stress in overweight and obese postmenopausal women with RA.
This study was a controlled, parallel-group superiority design in which 44 overweight and obese postmenopausal women with RA were randomly allocated to receive either IF (n = 22) or the usual diet (n = 22) for 8 weeks. The intervention group received 16/8 IF, and the control group received the typical diet for 8 weeks. The primary outcome was the Health Assessment Questionnaire-Disability Index (HAQ-DI) questionnaire score. The secondary outcomes included body mass index (BMI) and morning joint stiffness (MS) and biochemical indicators, including serum concentrations of erythrocyte sedimentation rate (ESR), high sensitive c-reactive protein (hs-CRP), and total oxidant and antioxidant capacity (TOC and TAC), and oxidative stress index (OSI), and interleukin 6 (IL-6) were assessed at the baseline and end of the study. Disease severity was assessed using the Disease Activity Score-28 (DAS-28) and Clinical Disease Activity Index (CDAI).
The IF diet significantly improved BMI, DAS-28, CDAI, and HAQ (p-value<0.05 for all). However, there were no significant effects on the other study outcomes.
IF has beneficial effects on some outcomes related to RA patients, while it has no significant impact on inflammation and oxidative stress markers. More studies are needed to determine IF's effects on RA patients.
类风湿关节炎（RA）属于风湿性疾病，是一种影响患者关节及身体其他部位的自身免疫性疾病。间歇性禁食（IF）是一种对多类人群都有有益影响的饮食模式。本随机对照试验（RCT）假设，间歇性禁食可改善超重和肥胖的绝经后类风湿关节炎女性患者的生活质量、临床症状、炎症及氧化应激水平。
本研究采用对照、平行组优效性设计，将44名超重和肥胖的绝经后类风湿关节炎女性患者随机分为两组，分别接受间歇性禁食（n = 22）或常规饮食（n = 22），为期8周。干预组采用16/8间歇性禁食方案，对照组接受常规饮食8周。主要结局指标为健康评估问卷残疾指数（HAQ-DI）问卷得分。次要结局指标包括体重指数（BMI）、晨僵（MS）以及生化指标，包括红细胞沉降率（ESR）、高敏C反应蛋白（hs-CRP）、总氧化剂和抗氧化剂能力（TOC和TAC）、氧化应激指数（OSI）以及白细胞介素6（IL-6），在研究基线和结束时进行评估。采用疾病活动评分28（DAS-28）和临床疾病活动指数（CDAI）评估疾病严重程度。
间歇性禁食饮食显著改善了BMI、DAS-28、CDAI和HAQ（所有p值均<0.05）。然而，对其他研究结局指标无显著影响。
间歇性禁食对类风湿关节炎患者的某些结局有有益影响，但对炎症和氧化应激标志物无显著影响。需要更多研究来确定间歇性禁食对类风湿关节炎患者的影响。
