Xiong Haibing, Li Letai, Luo Jiayu, Jiao Caiyun, Ye Meng, Lei Yang, Guo Xin, Zeng Shi, Huo Jianhong, Xiong Haofeng, Jiang Yingjiu, Leng Jiajie
Banan Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Department of Neurosurgery, Chengkou County People's Hospital, Chongqing, China.
Medicine (Baltimore). 2025 May 9;104(19):e42352. doi: 10.1097/MD.0000000000042352.
Nutritional and dietary interventions are important in the prevention of stroke, but many of the factors influencing stroke remain undefined. Although omega-3/6 polyunsaturated fatty acids (PUFAs) have been suggested to be associated with cerebrovascular diseases, studies on this topic are lacking. This study extracted and screened independent single nucleotide polymorphisms of omega-3/6 PUFAs and 3 types of cerebrovascular diseases data from the IEU Open GWAS database. A two-sample Mendelian randomization (MR) was used to examine the association between omega-3/6 PUFAs with subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and ischemic stroke (IS). The primary analysis method was the inverse variance weighting method, supplemented by the weighted median and MR-Egger methods. Sensitivity and multiplicity were assessed using Cochran Q test, MR-PRESSO, MR-Egger regression, and leave-one-out analysis. This study was conducted in full compliance with the STROBE guidelines throughout. The inverse variance weighting analysis revealed a negative correlation between omega-3 PUFAs and SAH (P = .0078). However, there was no correlation between omega-3 PUFAs and ICH (P = .3930) and IS (P = .2922). Additionally, there was no association between omega-6 PUFAs and SAH (P = .1399), ICH (P = .1399, 0.0660), and IS (P = .8571) using all 3 analytical methods. No heterogeneity or horizontal pleiotropy was observed. The study suggested that omega-3 PUFAs had a significant protective role in SAH. However, omega-3/6 PUFAs were not found to be associated with other types of cerebrovascular diseases.
营养和饮食干预对预防中风很重要，但许多影响中风的因素仍不明确。尽管有人提出ω-3/6多不饱和脂肪酸（PUFAs）与脑血管疾病有关，但关于这一主题的研究尚缺。本研究从IEU开放全基因组关联研究（GWAS）数据库中提取并筛选了ω-3/6 PUFAs的独立单核苷酸多态性和3种脑血管疾病的数据。采用两样本孟德尔随机化（MR）方法来研究ω-3/6 PUFAs与蛛网膜下腔出血（SAH）、脑出血（ICH）和缺血性中风（IS）之间的关联。主要分析方法是逆方差加权法，并辅以加权中位数法和MR-Egger法。使用Cochran Q检验、MR-PRESSO、MR-Egger回归和留一法分析来评估敏感性和多重性。本研究自始至终完全符合STROBE指南。逆方差加权分析显示ω-3 PUFAs与SAH之间呈负相关（P = 0.0078）。然而，ω-3 PUFAs与ICH（P = 0.3930）和IS（P = 0.2922）之间无相关性。此外，使用所有3种分析方法，ω-6 PUFAs与SAH（P = 0.1399）、ICH（P = 0.1399、0.0660）和IS（P = 0.8571）之间均无关联。未观察到异质性或水平多效性。该研究表明，ω-3 PUFAs对SAH具有显著的保护作用。然而，未发现ω-3/6 PUFAs与其他类型的脑血管疾病有关。
