Zhang W L, Zu Y L, Huang Z H, Li Z, Gui R R, Wang J, Wang X J, Wang H L, Fan X X, Song Y P, Fang B J, Zhou J
Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou 450008, China.
Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhonghua Xue Ye Xue Za Zhi. 2025 Mar 14;46(3):273-275. doi: 10.3760/cma.j.121090-20240810-00298.
A 20-year-old male patient with T-lymphoblastic lymphoma/leukemia received 9/10 human leukocyte antigen-compatible unrelated peripheral blood stem cell transplantation. He was transplanted with 5.91×10(8) mononuclear cells/kg and 2.88×10(6) CD34(+) cells/kg, and neutrophil engraftment was obtained at +11 days and platelet engraftment at +9 days. After transplantation, he presented with repeatedly increased serum creatinine levels, BK virus (BKV) -associated hemorrhagic cystitis, and BKV viremia. BK virus nephropathy was diagnosed based on renal biopsy and metagenomic next-generation sequencing. After adjusting the immunosuppressant, intravenous immunoglobulin, and donor lymphocyte infusion treatment, the patient's renal function deteriorated progressively, and he eventually died of multiple organ failure at +289 days.
一名患有T淋巴细胞母细胞淋巴瘤/白血病的20岁男性患者接受了9/10人类白细胞抗原相合的非亲缘外周血干细胞移植。他接受了5.91×10(8)个单核细胞/千克和2.88×10(6)个CD34(+)细胞/千克的移植，中性粒细胞在移植后第11天植入，血小板在移植后第9天植入。移植后，他出现血清肌酐水平反复升高、BK病毒（BKV）相关的出血性膀胱炎和BKV病毒血症。基于肾活检和宏基因组下一代测序诊断为BK病毒肾病。在调整免疫抑制剂、静脉注射免疫球蛋白和供体淋巴细胞输注治疗后，患者的肾功能逐渐恶化，最终在移植后第289天死于多器官功能衰竭。
