Tran Tanya, Keane Brian P, Thompson Judy L, Robinson Ben, Kenney Joshua, Williams Trevor F, Waltz James A, Levin Jason A, Kafadar Eren, Gold James M, Schiffman Jason, Ellman Lauren M, Walker Elaine F, Strauss Gregory P, Mittal Vijay A, Zinbarg Richard E, Corlett Philip R, Powers Albert R, Woods Scott W, Silverstein Steven M
Department of Psychiatry, University of Rochester Medical Center, Rochester, NY, USA.
Department of Psychiatry, University of Maryland School of Medicine, Catonsville, MD, USA.
Schizophrenia (Heidelb). 2025 May 12;11(1):74. doi: 10.1038/s41537-025-00624-y.
Altered visual perception has been observed across all phases of psychotic illness, suggesting that perceptual measures might be useful in identifying people at clinical high risk for psychosis (CHR). In a preliminary study, we found that CHR participants reported perceiving more faces in binarized human portraits on the Mooney Faces Test (MFT). Here, we aimed to replicate these findings and extend understanding of underlying processes and clinical correlates of MFT performance in the Computerized Assessment of Psychosis Risk (CAPR) cohort: CHR (n = 159), help-seeking psychiatric controls (n = 130), and healthy controls (n = 86). The MFT was adapted to include three image conditions (upright, inverted, and scrambled), and included follow-up questions regarding the physical characteristics of the faces that participants reported perceiving, to verify accuracy of perception and assess response bias. The CHR group reported more faces than both control groups in the inverted and scrambled conditions. In addition, the CHR group was as accurate at judging the age and gender of faces as the other groups. Among CHR participants, increased reporting of faces in the inverted condition was significantly correlated with more severe positive symptoms and poorer role functioning. We discuss the findings in terms of multiple perspectives, including changes in perceptual sensitivity, predictive coding, and perceptual organization.
在精神病性疾病的各个阶段均观察到了视觉感知的改变，这表明感知测量可能有助于识别临床高危精神病性状态（CHR）的人群。在一项初步研究中，我们发现CHR参与者在穆尼面部测试（MFT）的二值化人像中报告感知到更多的面孔。在此，我们旨在重复这些发现，并扩展对精神病风险计算机评估（CAPR）队列中MFT表现的潜在过程和临床相关性的理解：CHR组（n = 159）、寻求帮助的精神科对照组（n = 130）和健康对照组（n = 86）。MFT进行了调整，包括三种图像条件（正立、倒立和打乱），并包括关于参与者报告感知到的面孔的身体特征的后续问题，以验证感知的准确性并评估反应偏差。在倒立和打乱条件下，CHR组报告的面孔比两个对照组都多。此外，CHR组在判断面孔的年龄和性别方面与其他组一样准确。在CHR参与者中，倒立条件下面孔报告增加与更严重的阳性症状和更差的角色功能显著相关。我们从多个角度讨论了这些发现，包括感知敏感性的变化、预测编码和感知组织。
