Mohamed Amira Abdalla Abdelshafy, Soliman Ahmed S H, Mourad Shymaa Sobhy
Department of Animal Production, Faculty of Environmental Agricultural Sciences, Arish University, Al-Arish, North- Sinai, 45511, Egypt.
College of Veterinary Medicine, Northwest Agriculture and Forestry University, Yangling, 712100, China.
Sci Rep. 2025 May 12;15(1):16491. doi: 10.1038/s41598-024-82175-3.
Novel of hematopoietic system and hepatic system under the usage of antioxidant plants such as chia seeds and matcha green tea were critical sites in this study which promoted by crucial health of New-Zealand white (NZW) rabbits as a model for mammalia and eukaryotic cell. Our study investigated the effect of chia seeds and matcha green tea on the liver. Eighteen NZW rabbits average weighed of 547.08gm with an average age of 30 days were divided into three groups, control, chia seeds powder group 0.150gm/L, and matcha green tea group 0.075 gm/L. The weekly treatments were weighted from weaning age to marketing age about nine weeks were the experimental period. At the end of this experiment, we studied growth performance, metabolism, carcass characteristics, and some gene expression related to the growth factor family, hepatic metabolism, lipid profile, iron storage, and one of the endoplasmic reticulum stress receptors of NZW rabbits. The data in this study reported that final body weight increased significantly (P < 0.05) in the matcha group compared to the control, carcass trait and dressing parts were increased significantly in comparison to control. However, Red blood cell count, hemoglobin concentration, and ferritin increased in matcha groups in comparison to control while there is no difference significant between chia and control. Cortisol and insulin in plasma were decreased significantly in chia and matcha compared to control. IRP1, APOA2, IGF1, A1BG, and SLC27A5 were up-regulated in matcha tea groups compared to control while, SLC27A5 was down-regulated in chia groups and Leptin and GRP78 were showed down-regulated in chia and matcha groups. This study offers new insights into the role of chia seeds and matcha tea in physiological and biological processes in the liver and achieved a vital and healthy biological body and reduces the incidence of cancer.
在本研究中,以新西兰白兔作为哺乳动物和真核细胞模型,使用奇亚籽和抹茶等抗氧化植物对造血系统和肝脏系统的影响是关键研究点,这些植物对新西兰白兔的健康至关重要。我们的研究调查了奇亚籽和抹茶对肝脏的影响。将18只平均体重为547.08克、平均年龄为30天的新西兰白兔分为三组:对照组、0.150克/升奇亚籽粉组和0.075克/升抹茶组。从断奶期到上市期(约9周)的每周处理体重即为实验期。在本实验结束时,我们研究了新西兰白兔的生长性能、代谢、胴体特征以及一些与生长因子家族、肝脏代谢、血脂谱、铁储存和一种内质网应激受体相关的基因表达。本研究数据表明,与对照组相比,抹茶组的最终体重显著增加(P < 0.05),与对照组相比,胴体性状和屠宰部位显著增加。然而,与对照组相比,抹茶组的红细胞计数、血红蛋白浓度和铁蛋白增加,而奇亚籽组与对照组之间无显著差异。与对照组相比,奇亚籽组和抹茶组血浆中的皮质醇和胰岛素显著降低。与对照组相比,抹茶组中IRP1、APOA2、IGF1、A1BG和SLC27A5上调,而奇亚籽组中SLC27A5下调,奇亚籽组和抹茶组中瘦素和GRP78下调。本研究为奇亚籽和抹茶在肝脏生理和生物学过程中的作用提供了新的见解,并实现了一个重要且健康的生物体,降低了癌症发病率。