Orozco-Collazo Alfonso, Lizardo-Thiebaud María José, Rodríguez-Rodríguez Sergio, Montante-Montes de Oca Daniel, Riveros-Gilardi Berta, Sánchez-Hernández Beatriz, Seidman-Sorsby Alec, Monroy-Ramos Cinthya, Sandoval-López José Jesús, García-Carrera Isabel, Martínez-Baños Déborah
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Instituto Nacional de Pediatria, Mexico City, Mexico.
J Hematop. 2025 May 12;18(1):25. doi: 10.1007/s12308-025-00637-7.
Castleman disease is a clinicopathological entity that shares features with hematological, rheumatological, and infectious diseases, making accurate diagnosis essential. The objective of this study is to characterize the clinical and pathological characteristics of CD in a Mexican cohort. A retrospective study was conducted on adult Mexican patients diagnosed with unicentric (UCD) and multicentric (MCD) Castleman disease from 1985 to 2023. Clinical and histopathological characteristics typical of UCD and MCD were observed. POEMS-associated MCD showed a higher relapse rate. The mixed histopathological variant was more prevalent in MCD. Immunohistochemical expression of VEGF-A was elevated in all CD cases. A multidisciplinary diagnostic approach is crucial for accurately categorizing CD. The mixed histopathological variant was more common than previously reported, especially in MCD. Further studies are needed to validate VEGF-A as a biomarker for CD.
卡斯特曼病是一种临床病理实体，具有血液学、风湿病学和传染病的特征，因此准确诊断至关重要。本研究的目的是描述墨西哥队列中卡斯特曼病的临床和病理特征。对1985年至2023年诊断为单中心（UCD）和多中心（MCD）卡斯特曼病的成年墨西哥患者进行了回顾性研究。观察到UCD和MCD典型的临床和组织病理学特征。与POEMS相关的MCD显示出更高的复发率。混合组织病理学变体在MCD中更为普遍。所有卡斯特曼病病例中VEGF-A的免疫组化表达均升高。多学科诊断方法对于准确分类卡斯特曼病至关重要。混合组织病理学变体比以前报道的更为常见，尤其是在MCD中。需要进一步研究以验证VEGF-A作为卡斯特曼病的生物标志物。
