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手术切除的足踝肿物恶性肿瘤的预测因素:一项回顾性多中心研究

Predictors of malignancy in surgically removed foot and ankle masses: a retrospective multi-center study.

作者信息

Kanay Enes, Bulut Halil, Tutuncu Mehmed Nuri, Batibay Sefa, Demiröz Serdar, Okay Erhan, Ozkan Korhan

机构信息

Acıbadem University Ataşehir Hospital, Istanbul, Turkey.

Istanbul University Cerrahpaşa, Istanbul, Turkey.

出版信息

Eur J Orthop Surg Traumatol. 2025 May 12;35(1):188. doi: 10.1007/s00590-025-04338-w.

DOI:10.1007/s00590-025-04338-w
PMID:40355651
Abstract

PURPOSE

Foot and ankle masses, though uncommon, are an important subset of musculoskeletal tumors, encompassing benign and malignant forms. Malignant tumors often necessitate aggressive treatment, including amputation, and unplanned resections can worsen outcomes by increasing recurrence risk. Identifying predictors of malignancy and functional deficits is vital for improving treatment strategies.

METHODS

A retrospective review of 120 tumors in 112 patients (2017-2024) assessed demographics, tumor characteristics, size, surgical approach, and outcomes. Interventions included excision, curettage, and amputation, with reconstruction when needed. Predictors of malignancy and functional outcomes were statistically analyzed.

RESULTS

Malignancy was observed in 9.8% of cases, with tumor size > 45 mm and age > 45 years identified as significant predictors. The majority of surgeries were excisions (83.9%), followed by curettage in 13.3% and amputation in 2.8%. Complete resection (R0) was achieved in 94.5% of cases. Early-term (0-180 days) wound complications occurred in 5.4%, while late-term recurrence (median 22 months) was observed in 4.5% CONCLUSION: Tumor size and patient age are key malignancy predictors. Complete resection improves outcomes, highlighting the importance of tailored surgical planning.

摘要

目的

足踝部肿块虽不常见,但却是肌肉骨骼肿瘤的一个重要子集,包括良性和恶性类型。恶性肿瘤往往需要积极治疗,包括截肢,而计划外切除会因增加复发风险而使治疗结果恶化。识别恶性肿瘤和功能缺陷的预测因素对于改善治疗策略至关重要。

方法

对112例患者(2017 - 2024年)的120个肿瘤进行回顾性研究,评估人口统计学特征、肿瘤特征、大小、手术方式及治疗结果。干预措施包括切除、刮除和截肢,必要时进行重建。对恶性肿瘤和功能结果的预测因素进行统计学分析。

结果

9.8%的病例为恶性肿瘤,肿瘤大小>45 mm和年龄>45岁被确定为显著预测因素。大多数手术为切除术(83.9%),其次是刮除术(13.3%)和截肢术(2.8%)。94.5%的病例实现了完整切除(R0)。早期(0 - 180天)伤口并发症发生率为5.4%,晚期复发(中位时间22个月)发生率为4.5%。结论:肿瘤大小和患者年龄是恶性肿瘤的关键预测因素。完整切除可改善治疗结果,凸显了制定个性化手术计划的重要性。

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本文引用的文献

1
Osseous tumors of the foot, ankle, and lower leg: a cross-sectional observational study analysing 288 cases.足、踝及小腿部骨肿瘤:一项分析288例病例的横断面观察性研究。
J Foot Ankle Surg. 2025 Jan-Feb;64(1):79-85. doi: 10.1053/j.jfas.2024.09.008. Epub 2024 Oct 15.
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Insights into the Distribution Patterns of Foot and Ankle Tumours: Update on the Perspective of a University Tumour Institute.足踝部肿瘤分布模式的见解:大学肿瘤研究所视角的最新进展
J Clin Med. 2024 Jan 8;13(2):350. doi: 10.3390/jcm13020350.
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RESECTION OF ANKLE TUMOR LESION AND RECONSTRUCTION WITH THE USE OF ALLOGRAFT.
踝关节肿瘤病灶切除及同种异体骨移植重建
Acta Ortop Bras. 2023 Oct 23;31(5):e266018. doi: 10.1590/1413-785220233105e266018. eCollection 2023.
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Benign tumours of foot and ankle.足踝部良性肿瘤
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Malignant Bone and Soft Tissue Lesions of the Foot.足部恶性骨与软组织病变
J Clin Med. 2023 Apr 21;12(8):3038. doi: 10.3390/jcm12083038.
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Postoperative clinical and functional outcomes in patients with tumor and tumor-like lesion of foot and ankle.足部和踝部肿瘤和肿瘤样病变患者的术后临床和功能结果。
J Foot Ankle Res. 2022 Oct 14;15(1):75. doi: 10.1186/s13047-022-00582-z.
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Malignant Tumors of the Foot and Ankle.足部和踝部的恶性肿瘤。
Foot Ankle Int. 2022 Sep;43(9):1232-1241. doi: 10.1177/10711007221097654. Epub 2022 Jun 13.
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Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study.肿瘤位置和类型影响腱鞘巨细胞瘤的局部复发和关节损伤:一项多中心研究。
Sci Rep. 2021 Aug 30;11(1):17384. doi: 10.1038/s41598-021-96795-6.
9
Recurrence Rate After Wide Resection of Plantar Fibromatosis: A Case Series and Systematic Literature Review.足底纤维瘤病广泛切除后的复发率:病例系列和系统文献回顾。
Foot Ankle Spec. 2024 Apr;17(2):109-116. doi: 10.1177/19386400211032099. Epub 2021 Aug 8.
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An epidemiological review of 623 foot and ankle soft tissue tumours and pseudo-tumours.623 例足部和踝关节软组织肿瘤和假瘤的流行病学回顾。
Foot Ankle Surg. 2021 Jun;27(4):400-404. doi: 10.1016/j.fas.2020.05.004. Epub 2020 May 27.