Newman C G
Teratology. 1985 Aug;32(1):133-44. doi: 10.1002/tera.1420320118.
There is much misinformation in the medical community regarding the thalidomide syndrome. Some physicians and scientists are unaware of the fact that organs other than the limbs were frequently affected. Some believe that thalidomide could produce any type of limb reduction defect. Most were aware of the very narrow period of early organogenesis during which the thalidomide-type malformations could be produced. Important features include the fact that limb reduction defects were primarily preaxial, included concomitant girdle hypoplasia when limb reductions were severe, were almost universally bilateral and did not include distal transverse-type defects often called "hemimelia". While it can be said that some spontaneous (non-thalidomide) malformations can mimic the thalidomide syndrome, it can also be said that many limb reduction defects can be determined not to have been produced by thalidomide. The risks of the various defects can be estimated following exposure, with most certainty for limb defects, with less certainty for other defects. Many defects were not associated with exposure to thalidomide such as cleft lip and severe mental retardation.
在医学界，关于沙利度胺综合征存在很多错误信息。一些医生和科学家没有意识到除四肢外的其他器官也经常受到影响这一事实。一些人认为沙利度胺会导致任何类型的肢体减少缺陷。大多数人都知道在早期器官形成的非常狭窄的时期内，沙利度胺型畸形才可能产生。重要特征包括：肢体减少缺陷主要是轴前性的，当肢体减少严重时伴有带骨发育不全，几乎普遍是双侧的，且不包括通常称为“半肢畸形”的远端横向型缺陷。虽然可以说一些自发的（非沙利度胺引起的）畸形可能会模仿沙利度胺综合征，但也可以说许多肢体减少缺陷可以确定不是由沙利度胺引起的。接触后可以估计各种缺陷的风险，对于肢体缺陷最为确定，对于其他缺陷确定性较低。许多缺陷与接触沙利度胺无关，如唇裂和严重智力迟钝。
