Koskela Nea, Butt Julia, Michels Birgitta E, Syrjänen Kari, Grenman Seija, Waterboer Tim, Syrjänen Stina, Louvanto Karolina
Department of Obstetrics and Gynecology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Acta Obstet Gynecol Scand. 2025 Jul;104(7):1366-1372. doi: 10.1111/aogs.15105. Epub 2025 May 12.
Sexually transmitted infections caused by Chlamydia trachomatis and Mycoplasma genitalium can have significant implications during early childhood. This study aimed to assess maternal antibodies to C. trachomatis and M. genitalium in newborns, their vanishing, and offspring's own seroconversion to these pathogens during the first 3 years of life.
Altogether, 309 mother-neonate pairs originally enrolled in the prospective Finnish Family HPV (FFHPV) cohort study at Turku University Hospital, Finland, were analyzed for serum IgG antibodies to plasmid protein gene 3 (pGP3) for C. trachomatis and M. genitalium protein of adhesion (MgPa N-term) and recombinant MgPa for M. genitalium using multiplex serology, by serial sampling during a 3-year follow-up.
A significant correlation between maternal and neonate antibodies to both C. trachomatis and M. genitalium was evident up to 2 months after birth and to C. trachomatis also at 6 months (p < 0.001). During the first 3 years of life, three children seroconverted IgG antibodies to C. trachomatis and one to M. genitalium. At the last (36-month) follow-up visit, five (2.1%) children were seropositive for C. trachomatis and only one (0.4%) for M. genitalium.
Both C. trachomatis and M. genitalium IgG antibodies are transferred from the mother to her offspring during pregnancy; similarly, this is shown for nearly all maternal IgG antibodies. Seroconversion for both C. trachomatis and M. genitalium in early childhood was a rare event. Further studies are required to elucidate the significance of C. trachomatis and M. genitalium antibodies acquired in early life.
沙眼衣原体和生殖支原体引起的性传播感染在幼儿期可能具有重大影响。本研究旨在评估新生儿中针对沙眼衣原体和生殖支原体的母体抗体、这些抗体的消失情况以及子代在生命的前3年中自身针对这些病原体的血清学转换情况。
总共对最初纳入芬兰图尔库大学医院前瞻性芬兰家庭人乳头瘤病毒（FFHPV）队列研究的309对母婴进行了分析，通过多重血清学检测血清中针对沙眼衣原体质粒蛋白基因3（pGP3）、生殖支原体黏附蛋白（MgPa N端）以及生殖支原体重组MgPa的IgG抗体，并在3年随访期间进行系列采样。
出生后2个月内，母体和新生儿针对沙眼衣原体和生殖支原体的抗体之间存在显著相关性，出生后6个月时针对沙眼衣原体的抗体也存在显著相关性（p<0.001）。在生命的前3年中，3名儿童针对沙眼衣原体血清学转换为IgG抗体，1名儿童针对生殖支原体血清学转换为IgG抗体。在最后一次（36个月）随访时，5名（2.1%）儿童沙眼衣原体血清学阳性，仅1名（0.4%）儿童生殖支原体血清学阳性。
沙眼衣原体和生殖支原体的IgG抗体在孕期均从母体转移至子代；同样地，几乎所有母体IgG抗体都是如此。儿童期沙眼衣原体和生殖支原体的血清学转换均为罕见事件。需要进一步研究以阐明生命早期获得的沙眼衣原体和生殖支原体抗体的意义。
