沙眼衣原体和生殖支原体血浆抗体与上皮性卵巢肿瘤的关系
Chlamydia trachomatis and Mycoplasma genitalium plasma antibodies in relation to epithelial ovarian tumors.
作者信息
Idahl Annika, Lundin Eva, Jurstrand Margaretha, Kumlin Urban, Elgh Fredrik, Ohlson Nina, Ottander Ulrika
机构信息
Department of Clinical Science/Obstetrics & Gynecology, Umeå University, SE-901 87 Umeå, Sweden.
出版信息
Infect Dis Obstet Gynecol. 2011;2011:824627. doi: 10.1155/2011/824627. Epub 2011 Jul 28.
OBJECTIVE
To assess associations of Chlamydia trachomatis and Mycoplasma genitalium antibodies with epithelial ovarian tumors.
METHODS
Plasma samples from 291 women, undergoing surgery due to suspected ovarian pathology, were analyzed with respect to C. trachomatis IgG and IgA, chlamydial Heat Shock Protein 60-1 (cHSP60-1) IgG and M. genitalium IgG antibodies. Women with borderline tumors (n=12), ovarian carcinoma (n=45), or other pelvic malignancies (n=11) were matched to four healthy controls each.
RESULTS
Overall, there were no associations of antibodies with EOC. However, chlamydial HSP60-1 IgG antibodies were associated with type II ovarian cancer (P=.002) in women with plasma samples obtained >1 year prior to diagnosis (n=7). M. genitalium IgG antibodies were associated with borderline ovarian tumors (P=.01).
CONCLUSION
Chlamydial HSP60-1 IgG and M. genitalium IgG antibodies are in this study associated with epithelial ovarian tumors in some subsets, which support the hypothesis linking upper-genital tract infections and ovarian tumor development.
目的
评估沙眼衣原体和生殖支原体抗体与上皮性卵巢肿瘤的相关性。
方法
对291名因疑似卵巢病变而接受手术的女性的血浆样本进行分析，检测沙眼衣原体IgG和IgA、衣原体热休克蛋白60-1（cHSP60-1）IgG以及生殖支原体IgG抗体。将患有交界性肿瘤（n = 12）、卵巢癌（n = 45）或其他盆腔恶性肿瘤（n = 11）的女性与四名健康对照进行匹配。
结果
总体而言，抗体与上皮性卵巢癌无相关性。然而，在诊断前1年以上采集血浆样本的女性中（n = 7），衣原体HSP60-1 IgG抗体与II型卵巢癌相关（P = 0.002）。生殖支原体IgG抗体与交界性卵巢肿瘤相关（P = 0.01）。
结论
在本研究中，衣原体HSP60-1 IgG和生殖支原体IgG抗体在某些亚组中与上皮性卵巢肿瘤相关联，这支持了将上生殖道感染与卵巢肿瘤发生联系起来的假说。
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