Pomares-Bri Irene, Roca Marta, Borrás Fernando, Wabitsch Martin, Lahoz Agustín, Micol Vicente, Herranz-López María
Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche, Universidad Miguel Hernández (UMH), 03202 Elche, Spain.
Analytical Unit, Medical Research Institute-Hospital La Fe, Av. Fernando Abril Martorell 106, Valencia, 46026, Spain.
Food Res Int. 2025 Jun;211:116453. doi: 10.1016/j.foodres.2025.116453. Epub 2025 Apr 19.
Hyperglycemia leads to metabolic dysfunction in human adipocytes, characterized by decreased AKT phosphorylation, downregulation of glycolysis, TCA cycle, and amino acid metabolism, as well as altered lipid profiles. This study aimed to elucidate these metabolic alterations and evaluate the potential therapeutic effects of selected polyphenols. Comprehensive metabolic profiling revealed profound disruptions, including impaired carbon metabolism, amino acids, and lipids associated with obesity. Importantly, treatment with polyphenols, particularly verbascoside and ferulic acid, effectively mitigated these metabolic disturbances, restoring adipocyte homeostasis. The polyphenols increased metabolites from carbon metabolism and amino acids, improving glycolysis, the TCA cycle, and related pathways. They also modulated lipid profiles that are negatively associated with obesity and related diseases. These findings provide valuable insights into the metabolic pathways underlying adipocyte dysfunction in hyperglycemia and highlight the therapeutic potential of polyphenols in ameliorating metabolic disorders.
高血糖会导致人体脂肪细胞代谢功能障碍，其特征为AKT磷酸化降低、糖酵解、三羧酸循环和氨基酸代谢下调，以及脂质谱改变。本研究旨在阐明这些代谢改变，并评估所选多酚的潜在治疗效果。全面的代谢谱分析揭示了严重的紊乱，包括与肥胖相关的碳代谢、氨基酸和脂质受损。重要的是，多酚治疗，尤其是毛蕊花糖苷和阿魏酸，有效减轻了这些代谢紊乱，恢复了脂肪细胞的稳态。多酚增加了碳代谢和氨基酸的代谢产物，改善了糖酵解、三羧酸循环及相关途径。它们还调节了与肥胖及相关疾病呈负相关的脂质谱。这些发现为高血糖中脂肪细胞功能障碍的潜在代谢途径提供了有价值的见解，并突出了多酚在改善代谢紊乱方面的治疗潜力。
