Swan Laura Elizabeth
Department of Biochemistry, Cell and Systems Biology, University of Liverpool, Liverpool, United Kingdom.
Front Neurosci. 2025 Apr 28;19:1534061. doi: 10.3389/fnins.2025.1534061. eCollection 2025.
Bridge-like lipid transporters (BLTPs) have recently been revealed as key regulators of intraorganellar lipid trafficking, with their loss being associated with defective synaptic signalling and congenital neurological diseases. This group consists of five protein subfamilies [BLTP1-3, autophagy-related 2 (ATG2), and vacuolar protein sorting 13 (VPS13)], which mediate minimally selective lipid transfer between cellular membranes. Deceptively simple in both structure and presumed function, this review addresses open questions as to how bridge-like transporters work, the functional consequences of bulk lipid transfer on cellular signalling, and summarises some recent studies that have shed light on the surprising level of regulation and specificity found in this family of transporters.
桥状脂质转运蛋白（BLTPs）最近被揭示为细胞器内脂质转运的关键调节因子，其缺失与突触信号缺陷和先天性神经疾病有关。该蛋白家族由五个蛋白质亚家族组成[BLTP1 - 3、自噬相关蛋白2（ATG2）和液泡蛋白分选蛋白13（VPS13）]，它们介导细胞膜之间的低选择性脂质转移。尽管在结构和假定功能上看似简单，但本综述探讨了关于桥状转运蛋白如何工作、大量脂质转移对细胞信号传导的功能影响等悬而未决的问题，并总结了一些近期研究，这些研究揭示了该转运蛋白家族中令人惊讶的调控水平和特异性。
