Ruppert P H, Dean K F, Reiter L W
Toxicol Appl Pharmacol. 1985 Mar 30;78(1):69-77. doi: 10.1016/0041-008x(85)90306-0.
Cadmium (Cd), triethyltin (TET), and trimethyltin (TMT) are heavy metals which are neurotoxic to developing animals. In the present experiment, preweaning assessment of locomotor activity was used to detect and differentiate between the developmental toxicity of these metals. On postnatal day (PND) 5, rat pups received a single injection of either Cd, TET, or TMT. A within-litter design was used for dosing; 1 male and 1 female pup from each litter (N = 10 litters/compound) received either the vehicle, low, medium, or high dosage of the compound. Preweaning motor activity was assessed in 30-min sessions in figure-eight mazes from PND 13 to 21. Motor activity of control animals progressively increased in the initial days of testing, and then both within-session and between-session habituation developed. A single exposure to Cd, TET, and TMT produced hyperactivity by the end of the preweaning period but these metals differed in the day of peak activity, the onset of hyperactivity, and the development of habituation.
镉（Cd）、三乙基锡（TET）和三甲基锡（TMT）是对发育中的动物具有神经毒性的重金属。在本实验中，通过断奶前对运动活动的评估来检测和区分这些金属的发育毒性。在出生后第5天（PND 5），给幼鼠单次注射Cd、TET或TMT。给药采用同窝设计；每窝1只雄性和1只雌性幼鼠（每种化合物N = 10窝）接受溶剂对照、低、中或高剂量的化合物。从PND 13至21，在“8”字迷宫中以30分钟为时间段评估断奶前的运动活动。对照动物的运动活动在测试初期逐渐增加，然后在时间段内和不同时间段之间都出现了习惯化。单次接触Cd、TET和TMT在断奶前期结束时会导致多动，但这些金属在多动高峰期、多动开始时间以及习惯化发展方面存在差异。
