Saggu Shalini, Pless Andrew, Dew Emily, Ware Destany, Jiao Kai, Wang Qin
Department of Neuroscience and Regenerative Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Center for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, GA, United States.
Front Immunol. 2025 Apr 28;16:1543730. doi: 10.3389/fimmu.2025.1543730. eCollection 2025.
Monoamines, including norepinephrine, serotonin, and dopamine, orchestrate a broad spectrum of neurophysiological and homeostatic events. Recent research shows a pivotal role for monoaminergic signaling in modulating neuroinflammation by regulating proinflammatory cytokines and chemokines within the central nervous system. Importantly, this modulation is not unidirectional; released proinflammatory cytokines markedly "feedback" to influence the metabolism of monoamine neurotransmitters, impacting their synthesis, release, and reuptake. This bidirectional interplay significantly links monoaminergic pathways and neuroinflammatory responses. In this review, we summarize current knowledge of the dynamic interactions between monoamine signaling and neuroinflammation, as well as their critical implications for the pathophysiology of neuropsychiatric disorders, including Parkinson's Disease, Major Depressive Disorder, and Alzheimer's Disease. By integrating recent findings, we shed light on potential therapeutic targets within these interconnected pathways, providing insights into novel treatment strategies for these devastating disorders.
单胺类物质，包括去甲肾上腺素、血清素和多巴胺，协调着广泛的神经生理和体内平衡事件。最近的研究表明，单胺能信号传导在通过调节中枢神经系统内的促炎细胞因子和趋化因子来调节神经炎症方面起着关键作用。重要的是，这种调节并非单向的；释放的促炎细胞因子会显著“反馈”影响单胺类神经递质的代谢，影响其合成、释放和再摄取。这种双向相互作用显著地将单胺能通路与神经炎症反应联系起来。在这篇综述中，我们总结了关于单胺信号传导与神经炎症之间动态相互作用的当前知识，以及它们对神经精神疾病病理生理学的关键影响，包括帕金森病、重度抑郁症和阿尔茨海默病。通过整合最近的研究结果，我们揭示了这些相互关联通路中的潜在治疗靶点，为这些毁灭性疾病的新型治疗策略提供了见解。
