Song Jiulong, Fu Jian
College of Physical Education, Yangzhou University, Yangzhou, Jiangsu, China.
Front Nutr. 2025 Apr 28;12:1543674. doi: 10.3389/fnut.2025.1543674. eCollection 2025.
Osteoarthritis (OA) is one of the most prevalent chronic conditions among the elderly. The dietary index for gut microbiota (DI-GM) is a novel proposed indicator reflecting gut microbiome diversity. However, the role of DI-GM in OA remains unclear. This study thus aims to explore the association between DI-GM and the risk of OA and analyze the mediating roles of systemic immune-inflammation index (SII).
We utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007-2018. OA was assessed through self-reported questionnaires, and dietary recall data were used to calculate the DI-GM. Univariate and weighted multivariate logistic regression analyses were employed to evaluate the association between DI-GM and OA, the weighted linear regression analyses were employed to investigate the association of DI-GM with SII, while restricted cubic splines (RCS) curves were used to assess the non-linear relationship between these variables. Subgroup analyses were subsequently conducted to validate the robustness of the findings. Mediation analysis evaluated the role of SII.
This study included 15,875 participants, revealing a significant inverse association between the DI-GM and OA risk ( < 0.001), higher DI-GM demonstrated a substantially reduced OA risk (adjusted model OR: 0.83; 95% CI: 0.79-0.86) and were negatively associated with the SII [β (95% CI): -9.2 (-13.0, -2.0)]. The RCS curve indicated a non-linear relationship between DI-GM and OA risk. Subgroup analysis showed that various demographic and clinical factors did not significantly alter the association between DI-GM and OA risk (interaction -value > 0.05). The mediating effect of SII accounted for 12.69% of association between DI-GM and OA.
This study found a significant negatively association between DI-GM and OA prevalence in the US population. Mediation analyses demonstrated a significant mediating effect of SII.
骨关节炎（OA）是老年人中最常见的慢性疾病之一。肠道微生物群饮食指数（DI-GM）是一种新提出的反映肠道微生物群多样性的指标。然而，DI-GM在OA中的作用仍不清楚。因此，本研究旨在探讨DI-GM与OA风险之间的关联，并分析全身免疫炎症指数（SII）的中介作用。
我们利用了2007 - 2018年美国国家健康与营养检查调查（NHANES）的数据。通过自我报告问卷评估OA，并使用饮食回忆数据计算DI-GM。采用单因素和加权多因素逻辑回归分析来评估DI-GM与OA之间的关联，采用加权线性回归分析来研究DI-GM与SII的关联，同时使用限制立方样条（RCS）曲线来评估这些变量之间的非线性关系。随后进行亚组分析以验证研究结果的稳健性。中介分析评估了SII的作用。
本研究纳入了15875名参与者，结果显示DI-GM与OA风险之间存在显著的负相关（<0.001），较高的DI-GM表明OA风险大幅降低（调整模型OR：0.83；95%CI：0.79 - 0.86），并且与SII呈负相关[β（95%CI）：-9.2（-13.0，-2.0）]。RCS曲线表明DI-GM与OA风险之间存在非线性关系。亚组分析表明，各种人口统计学和临床因素并未显著改变DI-GM与OA风险之间的关联（交互P值>0.05）。SII的中介效应占DI-GM与OA之间关联的12.69%。
本研究发现美国人群中DI-GM与OA患病率之间存在显著的负相关。中介分析表明SII具有显著的中介作用。
