Department of Evidence-Based Medicine Center, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 441000, China.
Department of Burn and Plastic Surgery-Hand Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People's Hospital, Changshu, 215500, China.
Sci Rep. 2024 Jan 16;14(1):1357. doi: 10.1038/s41598-024-51523-8.
To explore the association between lipid markers and osteoarthritis (OA). First, the National Health and Nutrition Examination Survey (NHANES) database was used to screen participants with lipid markers, OA and relevant covariates, and logistic regression was used to analyze the association between lipid markers and OA; Then, under the theoretical framework of Mendelian randomization (MR), two-sample MR was performed using GWAS data of lipid markers and OA to explore the causal association between the two, which was analyzed by inverse variance weighting (IVW) method. Heterogeneity test, sensitivity analysis and pleiotropy analysis were also performed. The NHANES database screened a total of 3706 participants, of whom 836 had OA and 2870 did not have OA. When lipid markers were used as continuous variables, multivariate logistic results showed an association between HDL, LDL and OA (HDL, OR (95%):1.01 (1.00, 1.01); LDL, OR (95%):1.00 (0.99, 1.00)). When lipid markers were used as categorical variables, multivariate logistic results showed the fourth quartile result of 0.713 (0.513, 0.992) for LDL relative to the first quartile. In MR study, the results of the IVW method for TG, TL, HDL and LDL showed OR (95% CI) of 1.06 (0.97-1.16), 0.95 (0.85-1.06), 0.94 (0.86-1.02) and 0.89 (0.80-0.998) with P-values of 0.21, 0.37. 013, 0.046. The heterogeneity tests and multiplicity analyses showed P-values greater than 0.05, and sensitivity analyses showed no abnormal single nucleotide polymorphisms. Through NHANES database and MR analyses, LDL was found to be a protective factor for OA, while HDL still needs further study. Our results provide new biomarkers for preventive and therapeutic strategies for OA.
探讨血脂标志物与骨关节炎（OA）的相关性。方法：利用国家健康与营养调查（NHANES）数据库筛选出血脂标志物、OA 及相关协变量的参与者，采用 logistic 回归分析血脂标志物与 OA 的相关性；然后，基于孟德尔随机化（MR）的理论框架，利用血脂标志物和 OA 的 GWAS 数据进行两样本 MR 分析，探讨两者之间的因果关系，采用逆方差加权（IVW）法进行分析。还进行了异质性检验、敏感性分析和多效性分析。结果：NHANES 数据库共筛选出 3706 名参与者，其中 836 名患有 OA，2870 名未患有 OA。当血脂标志物作为连续变量时，多变量 logistic 结果显示 HDL 和 LDL 与 OA 相关（HDL，OR（95%）：1.01（1.00，1.01）；LDL，OR（95%）：1.00（0.99，1.01））。当血脂标志物作为分类变量时，多变量 logistic 结果显示 LDL 的第四四分位数结果为 0.713（0.513，0.992），与第一四分位数相比。MR 研究中，IVW 方法对于 TG、TL、HDL 和 LDL 的结果显示 OR（95%CI）分别为 1.06（0.97-1.16）、0.95（0.85-1.06）、0.94（0.86-1.02）和 0.89（0.80-0.998），P 值分别为 0.21、0.37、0.013 和 0.046。异质性检验和多重性分析显示 P 值均大于 0.05，敏感性分析显示没有异常的单核苷酸多态性。通过 NHANES 数据库和 MR 分析，发现 LDL 是 OA 的保护因素，而 HDL 仍需要进一步研究。结论：本研究为 OA 的预防和治疗策略提供了新的生物标志物。
