三氟甲磺酸银（I）催化的吡唑并二氮杂䓬的Ugi反应后合成。
Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines.
作者信息
Hasan Muhammad, Peshkov Anatoly A, Shah Syed Anis Ali, Belyaev Andrey, Lim Chang-Keun, Wang Shunyi, Peshkov Vsevolod A
机构信息
College of Chemistry Chemical Engineering and Material Science, Soochow University, Suzhou, 215123, P.R. China.
Department of Chemistry, School of Sciences and Humanities, Nazarbayev University, Astana, 010000, Kazakhstan.
出版信息
Beilstein J Org Chem. 2025 May 8;21:915-925. doi: 10.3762/bjoc.21.74. eCollection 2025.
A silver(I) triflate-catalyzed post-Ugi assembly of novel pyrazolo[1,5-][1,4]diazepine scaffolds is reported offering high yields (up to 98%) under mild conditions. The synthetic sequence involves the Ugi four-component reaction (U4CR) of pyrazole-3-carbaldehydes, primary amines, 3-substituted propiolic acids, and isocyanides, followed by a silver(I) triflate-catalyzed intramolecular heteroannulation of the resulting pyrazole-tethered propargylamides occurring in a 7-- fashion. The approach is scalable and tolerates a diverse range of substitution patterns.
据报道，一种三氟甲磺酸银（I）催化的新型吡唑并[1,5 - ][1,4]二氮杂卓支架的Ugi后组装反应，在温和条件下可提供高产率（高达98%）。合成序列包括吡唑 - 3 - 甲醛、伯胺、3 - 取代的炔丙酸和异腈的Ugi四组分反应（U4CR），随后是三氟甲磺酸银（I）催化的所得吡唑连接的炔丙酰胺的分子内杂环化反应，该反应以7 - 方式进行。该方法具有可扩展性，并且能够耐受多种取代模式。
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