Ebenezer Oluwakemi, Shapi Michael, Tuszynski Jack A
Department of Chemistry, Faculty of Natural Science, Mangosuthu University of Technology, Durban 4026, South Africa.
Department of Physics, University of Alberta, Edmonton, AB T6G 2E1, Canada.
Biomedicines. 2022 May 12;10(5):1124. doi: 10.3390/biomedicines10051124.
Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an important class of compounds for drug development; thus, they have attracted much attention. In the meantime, pyrazole derivatives have been synthesized as target structures and have demonstrated numerous biological activities such as antituberculosis, antimicrobial, antifungal, and anti-inflammatory. This review summarizes the results of published research on pyrazole derivatives synthesis and biological activities. The published research works on pyrazole derivatives synthesis and biological activities between January 2018 and December 2021 were retrieved from the Scopus database and reviewed accordingly.
吡唑是含氮的五元杂环化合物。它们是药物开发中一类重要的化合物，因此备受关注。与此同时，吡唑衍生物已被合成为目标结构，并已显示出多种生物活性，如抗结核、抗菌、抗真菌和抗炎活性。本综述总结了已发表的关于吡唑衍生物合成及生物活性的研究结果。从Scopus数据库中检索了2018年1月至2021年12月期间发表的关于吡唑衍生物合成及生物活性的研究工作，并进行了相应的综述。
