头孢吡肟诱导的神经毒性。
Cefepime-induced neurotoxicity.
作者信息
Taylor Jessica, Gunter Hannah M, Cohen Karen
机构信息
Division of Clinical Pharmacology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
出版信息
S Afr J Infect Dis. 2025 Apr 30;40(1):704. doi: 10.4102/sajid.v40i1.704. eCollection 2025.
UNLABELLED
We present a case of severe cefepime-induced neurotoxicity following acute kidney injury in a patient with a fracture-related infection. Despite stopping cefepime, the patient required intubation, ventilation, multiple antiepileptic drugs for seizure control, and haemodialysis.
CONTRIBUTION
Cefepime-induced neurotoxicity is a reversible cause of encephalopathy. Early recognition and cefepime withdrawal are crucial. As cefepime use in South Africa increases due to antimicrobial resistance, healthcare workers must be aware of this under-recognised, under-reported serious adverse drug reaction.
未标注
我们报告了一例骨折相关感染患者急性肾损伤后发生严重头孢吡肟诱导的神经毒性的病例。尽管停用了头孢吡肟，但患者仍需要插管、通气、使用多种抗癫痫药物来控制癫痫发作以及进行血液透析。
贡献
头孢吡肟诱导的神经毒性是脑病的一个可逆病因。早期识别和停用头孢吡肟至关重要。由于南非因抗菌药物耐药性导致头孢吡肟的使用增加，医护人员必须意识到这种未得到充分认识、报告不足的严重药物不良反应。
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