Wu Aixiang, Gai Wei, Guo Yuxin, Zhou Chenjie, Xu Yan, Zhang Xiaojing, Wang Huajun
Department of Pharmacy, The Affiliated People's Hospital of Ningbo University, Ningbo, China.
WillingMed Technology (Beijing) Co., Ltd., Beijing, China.
Front Med (Lausanne). 2025 Apr 28;12:1579522. doi: 10.3389/fmed.2025.1579522. eCollection 2025.
Talaromycosis, caused by (), has become more common in HIV-negative and immunocompetent patients. The fungus colonizes the body through dormant spores, causing opportunistic infections. Early diagnosis is challenging. This study aims to analyze the clinical features, diagnosis, treatment, and prognosis of infections.
Patients diagnosed with infection or colonization at the People's Hospital of Ningbo University between August 2022 and July 2024 were included. Demographic characteristics, clinical data, diagnostic approaches, and treatment outcomes were analyzed.
Seven patients were diagnosed with infection, and three with colonization. Productive cough and fever were the predominant symptoms in all patients. Nodules, cavitary lesions, and pleural effusions on chest imaging were observed exclusively in infected patients. The positivity rates for metagenomic next-generation sequencing (mNGS) and conventional microbiological testing were 100 and 10%, respectively. Of the seven infected patients, three had a single infection with , and four had co-infection with and . All patients were treated with monotherapy or combination therapy using voriconazole. All but one recovered.
Early diagnosis and combination therapy are critical for infection. mNGS complements traditional methods, facilitating accurate diagnosis and guiding targeted treatment.
由（）引起的足分支霉病在HIV阴性和免疫功能正常的患者中变得越来越常见。该真菌通过休眠孢子在体内定殖，引发机会性感染。早期诊断具有挑战性。本研究旨在分析（）感染的临床特征、诊断、治疗及预后。
纳入2022年8月至2024年7月期间在宁波大学人民医院被诊断为（）感染或定植的患者。分析其人口统计学特征、临床数据、诊断方法及治疗结果。
7例患者被诊断为（）感染，3例为定植。所有患者的主要症状为咳痰和发热。胸部影像学上的结节、空洞性病变及胸腔积液仅在感染患者中观察到。宏基因组下一代测序（mNGS）和传统微生物检测的阳性率分别为100%和10%。在7例感染患者中，3例为单一（）感染，4例为（）与（）合并感染。所有患者均接受伏立康唑单药治疗或联合治疗。除1例外，所有患者均康复。
早期诊断和联合治疗对（）感染至关重要。mNGS补充了传统方法，有助于准确诊断并指导靶向治疗。
