经盲肠内和肠系膜内途径感染的豚鼠肝阿米巴病的组织病理学
Histopathology of hepatic amoebiasis in guinea-pigs infected through intracaecal and intramesenteric routes.
作者信息
Gill N J, Ganguly N K, Bhusnurmath S R, Dilawari J B, Chakarvarty R N, Mahajan R C
出版信息
Trans R Soc Trop Med Hyg. 1985;79(3):339-43. doi: 10.1016/0035-9203(85)90374-8.
The comparative histopathological details of amoebic liver abscess were studied following intracaecal and intramesenteric inoculation of Entamoeba histolytica into guinea-pigs. The histological changes of amoebic liver abscess formed via the former route were similar to those seen in man. These consisted of a central necrotic area with few lymphomononuclear cells and E. histolytica trophozoites at the periphery of the lesion. The amoebic liver abscess formed via the intramesenteric route, however, differed from that formed by intracaecal inoculation in three ways: (i) in having an intense inflammatory reaction, (ii) healing of the abscess by fibrosis and (iii) exhibiting a giant cell reaction.
通过将溶组织内阿米巴接种到豚鼠盲肠内和肠系膜内，对阿米巴肝脓肿的比较组织病理学细节进行了研究。经前一种途径形成的阿米巴肝脓肿的组织学变化与人类所见相似。这些变化包括一个中央坏死区，在病变周边有少量淋巴单核细胞和溶组织内阿米巴滋养体。然而，经肠系膜内途径形成的阿米巴肝脓肿与经盲肠内接种形成的脓肿在三个方面有所不同：（i）有强烈的炎症反应，（ii）脓肿通过纤维化愈合，（iii）表现出巨细胞反应。
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