ALPK1-Dependent cIAP1 Degradation Regulates Helicobacter pylori-Induced Apoptosis.

Helicobacter pylori infection poses a significant risk for disrupting the gastric epithelium by inducing inflammation and apoptosis. Here, we identify alpha kinase 1 (ALPK1) as essential in H. pylori-induced apoptosis. The absence of ALPK1 leads to the accumulation of cellular inhibitor of apoptosis 1 (cIAP1) upon H. pylori infection, which raises the threshold for the induction of apoptosis. Ablation of cIAP1 with a SMAC-mimetic restores the level of apoptosis induced by H. pylori in these cells. Our findings highlight the impact of ALPK1 on the stability of cIAP1, influencing H. pylori-induced apoptosis.