Aanderud L, Bakke O M
Undersea Biomed Res. 1985 Mar;12(1):53-8.
Benzyl[14C]penicillin was infused at a constant rate of 100 mg X kg-1 X h-1 for 90 min in rats at 1 ATA air for the control group (n = 10) and at 71 ATA He-O2 for the pressure group (n = 11). The radioactivity was measured in the arterial blood, brain, liver, kidney, muscle, and fat. The mean brain penicillin concentration after 90 min infusion was approximately 20% increased at 71 ATA (P less than 0.05), but the brain: blood concentration ratio was not significantly affected. The mean blood, liver, and muscle penicillin content was slightly higher and the mean kidney content was slightly lower at pressure, but no statistically significant changes were observed.
对照组（n = 10）的大鼠在1个绝对大气压空气环境下，以100 mg·kg⁻¹·h⁻¹的恒定速率输注苄基[¹⁴C]青霉素90分钟；压力组（n = 11）的大鼠在71个绝对大气压的氦氧混合气环境下进行同样操作。测量动脉血、脑、肝、肾、肌肉和脂肪中的放射性。输注90分钟后，71个绝对大气压下脑内青霉素的平均浓度升高了约20%（P < 0.05），但脑血浓度比未受到显著影响。压力条件下，血液、肝和肌肉中的青霉素平均含量略高，肾中的平均含量略低，但未观察到统计学上的显著变化。
