脂肪组织衍生疗法治疗骨关节炎：多方面机制与临床前景

Zhang Hanwen, Felthaus Oliver, Prantl Lukas

Department of Plastic, Hand and Reconstructive Surgery, University Hospital Regensburg, Franz-Josef-Strauß Allee 11, 93053 Regensburg, Germany.

Cells. 2025 May 2;14(9):669. doi: 10.3390/cells14090669.

Osteoarthritis (OA) is a degenerative joint disease that significantly impacts quality of life and poses a growing economic burden. Adipose tissue-derived therapies, including both cell-based and cell-free products, have shown promising potential in promoting cartilage repair, modulating inflammation, and improving joint function. Recent studies and clinical trials have demonstrated their regenerative effects, highlighting their feasibility as a novel treatment approach for OA. This review summarises the therapeutic mechanisms and latest advancements in adipose tissue-derived therapies, providing insights into their clinical applications and future prospects.

骨关节炎（OA）是一种退行性关节疾病，会显著影响生活质量并带来日益沉重的经济负担。脂肪组织衍生疗法，包括基于细胞的产品和无细胞产品，在促进软骨修复、调节炎症和改善关节功能方面已显示出有前景的潜力。最近的研究和临床试验证明了它们的再生作用，突出了其作为OA新型治疗方法的可行性。这篇综述总结了脂肪组织衍生疗法的治疗机制和最新进展，为其临床应用和未来前景提供了见解。