Integration of brain-computer interfaces with sacral nerve stimulation: a vision for closed-loop, volitional control of bladder function in neurogenic patients through real-time cortical signal modulation and peripheral neuro-stimulation.

Sacral nerve stimulation (SNS) and brain-computer interfaces (BCI) are emerging neuromodulation therapies that offer innovative solutions for chronic neurological disorders. SNS, primarily used in the management of conditions such as urinary incontinence and chronic pelvic pain, demonstrates significant therapeutic potential. In contrast, BCIs are rapidly advancing in their ability to restore lost motor functions and improve the quality of life of patients with severe neurological impairments, such as spinal cord injury and stroke. The integration of SNS and BCI technologies presents a promising avenue for enhancing neuromodulation outcomes by leveraging the potential of both systems. This article explores the combined operation of SNS and BCI, addressing current challenges, future directions, and the potential for these combined therapies to revolutionise the field of functional neuromodulation.