Tamura Taichi, Tamura Takahiko, Okumura Kohki, Funakoshi Yusuke, Teranishi Hiroo
From the Tokyo Chuo Beauty Clinic Umeda Osaka Ekimae Clinic, Osaka, Japan.
Ann Plast Surg. 2025 Jun 1;94(6):630-633. doi: 10.1097/SAP.0000000000004327.
Hyaluronic acid (HA) injection as a facial filler is widely used for facial contouring and is generally believed to be safe and effective. Although extremely rare, serious complications, such as infection, skin necrosis due to vascular occlusion, and blindness, sometimes occur. No study has examined the rate of severe complications in high-volume cases in a single center. We analyzed large-scale data from a group of clinics throughout the country to evaluate the rate of severe complications associated with HA injections.
This retrospective study included the data of 209,083 patients (290,307 injection sites) from our database between October 2020 and April 2024. We analyzed 12 cases of serious complications, such as infection and vascular obstruction.
There were 290,307 HA injections, including 2 cases of infection and 10 cases of vascular obstruction. The incidence of severe complications was 0.0041%. There was one case each of infection of the chin and nasolabial folds (NLF), 1 case of vascular embolization of the NLF and nose, and 8 cases of vascular embolization of the forehead.
The rate of severe complications associated with HA injections was low. However, more attention is necessary to further lower the complication rates.
透明质酸（HA）注射作为一种面部填充剂被广泛用于面部轮廓塑形，一般认为是安全有效的。尽管极为罕见，但严重并发症，如感染、血管阻塞导致的皮肤坏死和失明等，有时仍会发生。尚无研究在单一中心调查大量病例中严重并发症的发生率。我们分析了来自全国一组诊所的大规模数据，以评估与HA注射相关的严重并发症发生率。
这项回顾性研究纳入了2020年10月至2024年4月我们数据库中209,083例患者（290,307个注射部位）的数据。我们分析了12例严重并发症，如感染和血管阻塞。
共进行了290,307次HA注射，其中感染2例，血管阻塞10例。严重并发症的发生率为0.0041%。下巴和鼻唇沟（NLF）感染各1例，NLF和鼻子血管栓塞1例，额头血管栓塞8例。
与HA注射相关的严重并发症发生率较低。然而，需要更多关注以进一步降低并发症发生率。
