Moreno-Valladares Antonio, Vinokurtseva Anastasiya, González-Rodríguez Johanna M, Ahmed Iqbal I K, Gonzalez-Aquino Eva, Puerto-Amorós Nieves, Roquet Esther, Soldevila Anna, Canut María I
University Hospital of Albacete, Albacete.
Prism Eye Institute, Mississauga.
J Glaucoma. 2025 Aug 1;34(8):585-590. doi: 10.1097/IJG.0000000000002590. Epub 2025 May 13.
Combined phaco-ELIOS in ocular hypertension and glaucoma showed a statistically significant reduction in the number of hypotensive medications of 1.5 compared with baseline, with 78.4% of eyes being medication-free at 12 months.
To describe the change in medication and intraocular pressure 12 months after the combined phacoemulsification-ELIOS procedure.
Retrospective, multicenter interventional case series of adults with ocular hypertension or glaucoma undergoing phaco-ELIOS. Clinical data were collected and analyzed from preoperative baseline up to 12 months postoperatively. The primary outcome was the mean change in medication compared with baseline. Secondary outcomes were intraocular pressure change from baseline, incidence of acute postoperative intraocular pressure elevation, and surgical success at 1 year, defined as intraocular pressure reduction of ≥20% compared with baseline with no increase in medications, or reduction of ≥1 medications compared with baseline with intraocular pressure equal or below baseline, with no secondary glaucoma surgeries and no loss of light perception.
One hundred twelve eyes were included. Forty-two patients (51.2%) were female. Mean (±SD) age was 70.6 (±9.6) years. The most frequent diagnosis was primary open angle glaucoma (71.4%). The mean number of medications at baseline and 12 months was 1.8 (±0.8) and 0.4 (±0.7), respectively, representing a reduction of 1.5 (±1.0) ( P <0.0001). At the end of follow-up, 78.4% of eyes were medication-free. Mean intraocular pressure at baseline and 12 months was 19.9 (±4.0) mm Hg and 16.7 (±2.6) mm Hg, respectively, a significant decrease of 3.2 mm Hg (±4.0) or 13.7% ( P <0.0001). Surgical success was achieved in 75.9% of eyes at 12 months.
Combined phaco-ELIOS in glaucoma significantly reduced medication use and IOP, with over 75% of eyes being medication-free at 12 months.
在高眼压症和青光眼患者中联合使用白内障超声乳化术和ELIOS，与基线相比，降压药物数量在统计学上显著减少了1.5种，在12个月时78.4%的眼睛无需使用药物。
描述白内障超声乳化术-ELIOS联合手术后12个月时药物使用情况和眼压的变化。
对接受白内障超声乳化术-ELIOS的高眼压症或青光眼成年患者进行回顾性、多中心介入性病例系列研究。收集并分析从术前基线到术后12个月的临床数据。主要结局是与基线相比药物使用的平均变化。次要结局包括与基线相比眼压的变化、术后急性眼压升高的发生率以及1年时的手术成功率，手术成功定义为与基线相比眼压降低≥20%且药物使用无增加，或与基线相比药物减少≥1种且眼压等于或低于基线，无继发性青光眼手术且无光感丧失。
纳入112只眼睛。42名患者（51.2%）为女性。平均（±标准差）年龄为70.6（±9.6）岁。最常见的诊断是原发性开角型青光眼（71.4%）。基线和12个月时药物的平均数量分别为1.8（±0.8）种和0.4（±0.7）种，减少了1.5（±1.0）种（P<0.0001）。随访结束时，78.4%的眼睛无需使用药物。基线和12个月时的平均眼压分别为19.9（±4.0）mmHg和16.7（±2.6）mmHg，显著降低了3.2mmHg（±4.0）或13.7%（P<0.0001）。12个月时75.9%的眼睛手术成功。
青光眼患者联合使用白内障超声乳化术和ELIOS可显著减少药物使用和眼压，12个月时超过75%的眼睛无需使用药物。
