Zhong Qian, Ren Li, Wang Tianhong, An Zhenmei, Hua Yusi
Department of Endocrinology, West China Hospital, Sichuan University, Chengdu, China.
Division of Vascular Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.
PLoS One. 2025 May 13;20(5):e0323211. doi: 10.1371/journal.pone.0323211. eCollection 2025.
Recently, circadian syndrome (CircS) is proposed as a novel risk cluster based on sleep disorder, depression, dyslipidemia, hyperglycemia, hypertension and abdominal obesity. To investigate the association between CircS and possible sarcopenia, this study was performed.
Possible sarcopenia is defined according to Asian Working Group for Sarcopenia in 2019, which includes measures of muscle strength and physical performance. In the baseline survey, 7,905 participants aged ≥ 40 years from the China Health and Retirement Longitudinal Study were included. Multivariate logistic regression was used to evaluate the association between CircS and possible sarcopenia. Subgroup and interactive analyses were adopted to verify the findings in the overall population and identify potential interactive effects. The obese population was excluded and the missing values were interpolated using multivariate imputation by chained equations as sensitivity analyses. In addition, the participants were followed up for four years to explore the longitudinal association between CircS and incident possible sarcopenia.
As per one increase of CircS components, participants had a 1.11-fold (95% CI = 1.07-1.14, P < 0.001) risk of prevalent possible sarcopenia in the full model. The CircS group was associated with a 1.30-fold (95% CI = 1.17-1.44) risk of prevalent possible sarcopenia (P < 0.001). No significant interactive effects of covariates on the association between CircS and prevalent possible sarcopenia were detected (all P for interaction > 0.05). All the subgroup and sensitivity analyses supported the positive association between CircS and possible sarcopenia. In the longitudinal follow-up, the odd ratio was 1.06 (95% CI = 1.00-1.13, P < 0.05) as per one increase of CircS components in the full model. The CircS group was also found to have an elevated risk of incident possible sarcopenia (odd ratio = 1.24, 95% CI = 1.03-1.50, P < 0.05) after adjusting all the covariates.
CircS is a risk factor for possible sarcopenia, which may serve as a predictor of possible sarcopenia for early identification and intervention.
最近，昼夜节律综合征（CircS）被提出作为一种基于睡眠障碍、抑郁、血脂异常、高血糖、高血压和腹部肥胖的新型风险集群。为了研究CircS与可能的肌肉减少症之间的关联，开展了本研究。
根据2019年亚洲肌肉减少症工作组的定义确定可能的肌肉减少症，其中包括肌肉力量和身体表现的测量。在基线调查中，纳入了来自中国健康与养老追踪调查的7905名年龄≥40岁的参与者。采用多因素逻辑回归评估CircS与可能的肌肉减少症之间的关联。采用亚组分析和交互分析来验证总体人群中的研究结果，并识别潜在的交互作用。作为敏感性分析，排除肥胖人群，并使用链式方程多变量插补法对缺失值进行插补。此外，对参与者进行了四年的随访，以探讨CircS与新发可能的肌肉减少症之间的纵向关联。
在全模型中，CircS成分每增加一项，参与者患现患可能肌肉减少症的风险增加1.11倍（95%CI=1.07-1.14，P<0.001）。CircS组患现患可能肌肉减少症的风险增加1.30倍（95%CI=1.17-1.44）（P<0.001）。未检测到协变量对CircS与现患可能肌肉减少症之间的关联有显著交互作用（所有交互作用P>0.05）。所有亚组分析和敏感性分析均支持CircS与可能的肌肉减少症之间存在正相关。在纵向随访中，在全模型中，CircS成分每增加一项，比值比为1.06（95%CI=1.00-1.13，P<0.05）。在调整所有协变量后，还发现CircS组新发可能肌肉减少症的风险升高（比值比=1.24，95%CI=1.03-1.50，P<0.05）。
CircS是可能的肌肉减少症的一个风险因素，可作为可能的肌肉减少症的预测指标，用于早期识别和干预。
