基因启动子在基因组上进行编码，以促进组蛋白交换/整合。
Gene promoters are genomically encoded to facilitate histone exchange/incorporation.
作者信息
Bartholomew Blaine
机构信息
University of Texas, MD Anderson Cancer Center, Houston, Texas, United States of America.
出版信息
PLoS Biol. 2025 May 13;23(5):e3003160. doi: 10.1371/journal.pbio.3003160. eCollection 2025 May.
Abstract
Gene promoters are intrinsically hardwired not only to facilitate transcription preinitiation complex formation but also the release of paused RNA polymerase by H2A.Z. A new PLOS Biology study reveals poly (dA) tracts at promoters positively stimulate H2A.Z incorporation by the SWR complex in yeast.
摘要
基因启动子本质上不仅有助于转录前起始复合物的形成，还能促进H2A.Z介导的暂停RNA聚合酶的释放。《公共科学图书馆·生物学》的一项新研究表明，酵母启动子处的聚（dA）序列能正向刺激SWR复合物介导的H2A.Z整合。
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