Raĭkhlin N T, Katenkamp D, Vattsig V
Vopr Onkol. 1985;31(8):42-8.
The study is concerned with the results of light and electron microscopic examination of 2 cases of neuroendocrine (Merkel cell) carcinoma of the skin. Both patients developed multiple widely-distributed intra- and subcutaneous nodules. Histologically, tumors were mostly trabecular. Electron microscopic examination revealed neuroendocrine secretory granules, small bundles of intermediate fibers, a well-defined Golgi complex and a relatively high level of vesicular structures. There were some basal membrane fragments. It is suggested that they originate from polypotential epithelial stem cells.
本研究关注2例皮肤神经内分泌（默克尔细胞）癌的光镜和电镜检查结果。两名患者均出现多发且广泛分布的体内及皮下结节。组织学上，肿瘤大多呈小梁状。电镜检查显示有神经内分泌分泌颗粒、小束中间丝、发育良好的高尔基体复合体以及相对较高水平的囊泡结构。存在一些基底膜碎片。提示它们起源于多能上皮干细胞。
