Bretza J A, Novey H S
West J Med. 1985 Jul;143(1):55-9.
Seven patients had anaphylactoid reactions after ingesting tolmetin sodium. In each case the reaction followed readministration of the drug after an interrupted period of at least three days and within 90 minutes of taking a single 400-mg capsule. None of the patients had had prior anaphylaxis and none were judged atopic. Skin tests to an extract of the drug (0.02 mg) were uniformly negative, whereas a higher concentration produced a nonspecific irritant reaction. In vitro tests in one patient for IgE antibodies to tolmetin and for complement activation were negative.
7名患者在摄入托美汀钠后发生类过敏反应。在每种情况下，反应均发生在至少中断用药三天后再次给药，且在服用一粒400毫克胶囊后的90分钟内。所有患者既往均无过敏反应，且均未被判定为特应性体质。对该药物提取物（0.02毫克）进行的皮肤试验均为阴性，而较高浓度则产生非特异性刺激性反应。对一名患者进行的托美汀IgE抗体和补体激活的体外试验均为阴性。
