In Kyungryun, Kang Sunhyung, Lee Hyunseok, Eun Hyuksoo, Moon Heeseok, Lee Eaumseok, Kim Seokhyun, Sung Jaekyu, Lee Byungseok
Division of Gastroenterology, Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.
Cancers (Basel). 2025 Apr 23;17(9):1415. doi: 10.3390/cancers17091415.
Disease recurrence is the primary cause of death in patients with gastric cancer who have undergone complete surgical resection. No prognostic factors for recurrence, other than the Tumor, Node, and Metastasis stage, have been established. However, recurrence rates differ even within the same Tumor, Node, and Metastasis stage. Therefore, we aimed to develop a new prognostic confidence measure for gastric cancer recurrence and demonstrate its practical utility.
This was a retrospective study based on the medical records of the Chungnam National University Hospital, Republic of Korea. We enrolled patients diagnosed with stage II/III gastric cancer who underwent complete surgical resection and adjuvant chemotherapy over the past 12 years. The association between seven variables, including the systemic inflammation response index (SIRI) and gastric cancer recurrence, was analyzed.
A total of 296 patients were enrolled in this study. Although other factors did not exhibit significant correlations, SIRI showed a significant positive correlation with gastric cancer recurrence risk, confirmed through Cox regression testing (hazard ratio, 1.231; 95% confidence interval, 1.04-1.45). Linear regression analysis revealed a significant association between higher SIRI values and shorter recurrence time ( = 0.044; β = -0.225).
In this study, other than SIRI, effective prognostic factors related to gastric cancer recurrence were not verified, thus indicating SIRI as a potential independent prognostic factor.
疾病复发是接受了完整手术切除的胃癌患者的主要死亡原因。除了肿瘤、淋巴结和转移分期外，尚未确立复发的预后因素。然而，即使在相同的肿瘤、淋巴结和转移分期内，复发率也有所不同。因此，我们旨在开发一种新的胃癌复发预后置信度测量方法，并证明其实际应用价值。
这是一项基于韩国忠南国立大学医院病历的回顾性研究。我们纳入了在过去12年中被诊断为II/III期胃癌并接受了完整手术切除和辅助化疗的患者。分析了包括全身炎症反应指数（SIRI）在内的七个变量与胃癌复发之间的关联。
本研究共纳入296例患者。虽然其他因素未显示出显著相关性，但通过Cox回归检验证实，SIRI与胃癌复发风险呈显著正相关（风险比，1.231；95%置信区间，1.04 - 1.45）。线性回归分析显示，较高的SIRI值与较短的复发时间之间存在显著关联（ = 0.044；β = -0.225）。
在本研究中，除SIRI外，未证实与胃癌复发相关的有效预后因素，因此表明SIRI是一个潜在的独立预后因素。
