Feuer G, Waheed Roomi M, Stuhne-Sekalec L, Cameron R G
Xenobiotica. 1985 May;15(5):407-12. doi: 10.3109/00498258509045011.
The effect of cobalt protoporphyrin IX (Co-haem) given to male rats in single subcutaneous doses (25-100 mumol/kg body wt.) was studied. Co-haem decreased cytochrome P-450 content and aminopyrine N-demethylase activity, but increased progesterone content and 3H-progesterone binding in a dose-related manner. The effect of a single dose of 50 mumol/kg body wt. was reversible; cytochrome P-450 and progesterone content, and progesterone binding, returned to the normal level 24-40 d after injection but aminopyrine N-demethylase activity was only partially restored. The converse actions of Co-haem on microsomal progesterone and cytochrome P-450 content showed high correlation.
研究了给雄性大鼠单次皮下注射不同剂量（25 - 100 μmol/kg体重）的钴原卟啉IX（Co-血红素）的效果。Co-血红素可降低细胞色素P-450含量和氨基比林N-脱甲基酶活性，但以剂量相关的方式增加孕酮含量和3H-孕酮结合。50 μmol/kg体重的单次剂量的作用是可逆的；细胞色素P-450和孕酮含量以及孕酮结合在注射后24 - 40天恢复到正常水平，但氨基比林N-脱甲基酶活性仅部分恢复。Co-血红素对微粒体孕酮和细胞色素P-450含量的相反作用显示出高度相关性。
