口服给药后大鼠、兔、犬及人体中卡比咪嗪的代谢情况。

Carpipramine metabolism in the rat, rabbit and dog and in man after oral administration.

作者信息

Bieder A, Decouvelaere B, Gaillard C, Gaillot J, Depaire H, Raynaud L, Snozzi C

出版信息

Xenobiotica. 1985 May;15(5):421-35. doi: 10.3109/00498258509045013.

Abstract

Carpipramine administered orally is excreted via the urine and faeces in rat, rabbit, dog and man. Many metabolites are formed, including several conjugates in the urine. A total of 20-25 metabolites was detected by t.l.c. and h.p.l.c., 16 of which were isolated and identified. Three metabolic pathways were observed: hydroxylation of the iminodibenzyl ring to a phenol or alcohol without modification of the side-chain, hydroxylation of the terminal piperidine of the 2-piperidinol side-chain, and cyclization and dehydrogenation of the same 2-piperidinol group.

摘要

口服卡比咪嗪后，在大鼠、兔子、狗和人体中均通过尿液和粪便排泄。会形成许多代谢产物，包括尿液中的几种结合物。通过薄层层析（t.l.c.）和高效液相色谱法（h.p.l.c.）共检测到20 - 25种代谢产物，其中16种已被分离和鉴定。观察到三种代谢途径：亚氨基二苄环羟基化为苯酚或醇，侧链不变；2 - 哌啶醇侧链末端哌啶羟基化；以及同一2 - 哌啶醇基团的环化和脱氢。