Liu Duqiu, Yang Chenxing, Guo Tianyu, Guo Yi, Xiong Jinjie, Chen Ru, Deng Shan
Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Liyuan Cardiovascular Center, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, China.
Healthcare (Basel). 2025 Apr 28;13(9):1018. doi: 10.3390/healthcare13091018.
: The relationship between sarcopenia and the incidence of coronary artery disease (CAD) is not well understood. This study aimed to investigate this relationship and the modifying effect of potential risk factors. : We conducted a prospective study including 439,295 individuals from the UK Biobank. The primary outcome was the incidence of CAD. The main physical capability markers for sarcopenia, grip strength and muscle mass, were investigated as risk factors of interest. Grip strength was measured using a Jamar J00105 (Lafayette, IN, USA) hydraulic hand dynamometer, while muscle mass was estimated through bioelectrical impedance. Cox proportional hazard models were employed to analyze the associations between the exposures and the risk of CAD. : A total of 41,564 incident cases of CAD were identified after a median follow-up of 13.15 years (IQR 12.29-13.88 years). Compared with the lowest quintile of grip strength, the adjusted HRs for incidences of CAD from the second to the fifth quintile were 0.81 (95% CI: 0.79-0.83), 0.71 (95% CI: 0.69-0.73), 0.61 (95% CI: 0.60-0.63), and 0.49 (95% CI: 0.48-0.51). The association remained significant in subgroup analysis and interactions were observed between the two exposures and sex, age, smoking status, inflammatory diseases, metabolic syndrome, and genetic predisposition (all for interactions < 0.05). : Physical capability markers of sarcopenia, grip strength and muscle mass, were independently associated with a dose-response decreased risk for CAD incidence, regardless of genetic predisposition and potential modifying risk factors.
肌肉减少症与冠状动脉疾病（CAD）发病率之间的关系尚未完全明确。本研究旨在调查这种关系以及潜在风险因素的调节作用。我们进行了一项前瞻性研究，纳入了英国生物银行的439,295名个体。主要结局是CAD的发病率。研究了肌肉减少症的主要身体能力指标握力和肌肉量，将其作为感兴趣的风险因素。使用Jamar J00105（美国印第安纳州拉斐特市）液压式握力计测量握力，通过生物电阻抗估算肌肉量。采用Cox比例风险模型分析暴露因素与CAD风险之间的关联。在中位随访13.15年（四分位间距12.29 - 13.88年）后，共识别出41,564例CAD发病病例。与握力最低的五分位数相比，第二至第五五分位数的CAD发病率调整后风险比分别为0.81（95%置信区间：0.79 - 0.83）、0.71（95%置信区间：0.69 - 0.73）、0.61（95%置信区间：0.60 - 0.63）和0.49（95%置信区间：0.48 - 0.51）。在亚组分析中该关联仍然显著，并且观察到这两种暴露因素与性别、年龄、吸烟状况、炎症性疾病、代谢综合征和遗传易感性之间存在相互作用（所有相互作用P值<0.05）。肌肉减少症的身体能力指标握力和肌肉量与CAD发病率的风险呈剂量反应性降低独立相关，无论遗传易感性和潜在的调节风险因素如何。
