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盐度诱导的大黄鱼HPI轴对免疫相关基因表达的调控

Regulation of Immune-Related Gene Expression by Salinity-Induced HPI Axis in Large Yellow Croaker, .

作者信息

Cheng Jia, Lou Zhengjia, Feng Huijie, Zhang Yu, Li Honghui, Chu Wuying, Xue Liangyi

机构信息

College of Marine Sciences, Ningbo University, Ningbo 315832, China.

College of Biological and Chemical Engineering, Changsha University, Changsha 410022, China.

出版信息

Int J Mol Sci. 2025 May 1;26(9):4298. doi: 10.3390/ijms26094298.

DOI:10.3390/ijms26094298
PMID:40362534
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12072655/
Abstract

Large yellow croaker is one of the most popular economic fish species in China. There are studies on the effects of salinity on the growth and development of large yellow croaker (), but the effects of the hypothalamic-pituitary-interrenal axis (HPI), HPI axis-related genes, and immune-related gene expression and its mechanisms have not been reported. This study analyzed the comparative transcriptomics of brain tissue in large yellow croaker under different salinity (12, 24, and 36 ppt) treatments for 4 weeks. The results showed that there were 1568 differential expression genes in the high salinity (HB) and normal salinity (NB) groups, including 494 up-regulated and 1074 down-regulated transcripts, and 1720 differential expression genes in the low salinity (LB) and normal salinity (NB) groups, including 486 up-regulated and 1234 down-regulated transcripts. Some pathways were significantly enriched, including the adrenergic signaling pathway of cardiomyocytes, oxidative phosphorylation, aldosterone synthesis and secretion, chemokine signaling pathway, and cyclic adenosine monophosphate (cAMP) signaling pathway. Quantitative Real-time polymerase chain reaction (qPCR) analysis further confirmed changes in the expression levels of HPI axis-related genes (, , and ) and significant changes in the expression levels of immune-related genes (, , , , , , , and ). In summary, this experiment demonstrates that salinity stress can activate the HPI axis and influence its immune function in large yellow croaker. Furthermore, the expression of immune factors during the immune response is regulated by the upstream genes of the HPI axis. The findings of this study are significant for understanding the physiological and immune responses of large yellow croaker to salinity stress.

摘要

大黄鱼是中国最受欢迎的经济鱼类之一。已有关于盐度对大黄鱼生长发育影响的研究（），但下丘脑 - 垂体 - 肾间组织轴（HPI）、HPI轴相关基因以及免疫相关基因表达及其机制的影响尚未见报道。本研究分析了在不同盐度（12、24和36 ppt）处理4周的大黄鱼脑组织的比较转录组学。结果显示，高盐度（HB）组和正常盐度（NB）组中有1568个差异表达基因，包括494个上调转录本和1074个下调转录本，低盐度（LB）组和正常盐度（NB）组中有1720个差异表达基因，包括486个上调转录本和1234个下调转录本。一些通路显著富集，包括心肌细胞的肾上腺素能信号通路、氧化磷酸化、醛固酮合成与分泌、趋化因子信号通路和环磷酸腺苷（cAMP）信号通路。实时定量聚合酶链反应（qPCR）分析进一步证实了HPI轴相关基因（、和）表达水平的变化以及免疫相关基因（、、、、、、和）表达水平的显著变化。综上所述，本实验表明盐度胁迫可激活大黄鱼的HPI轴并影响其免疫功能。此外，免疫反应过程中免疫因子的表达受HPI轴上游基因的调控。本研究结果对于理解大黄鱼对盐度胁迫的生理和免疫反应具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/3b02c39cd0e5/ijms-26-04298-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/3b02c39cd0e5/ijms-26-04298-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/76e02fbaf848/ijms-26-04298-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/67b4571c9494/ijms-26-04298-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/febdfcfd1c90/ijms-26-04298-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/62c5e1209774/ijms-26-04298-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/8a275c4c16f9/ijms-26-04298-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56d9/12072655/3b02c39cd0e5/ijms-26-04298-g013.jpg

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