Olas Beata
Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236 Lodz, Poland.
Int J Mol Sci. 2025 May 5;26(9):4380. doi: 10.3390/ijms26094380.
The genus has been found to exhibit different biological properties, including antioxidant, anticancer, and others. For example, is a classical traditional herb used in various Asian countries, especially China, South Korea, and Japan. Magnolia bark is the main medicinal part of this plant. This paper reviews the current state of knowledge regarding the bark and its active constituents, especially magnolol and honokiol, with a special emphasis on their cardioprotective activity in various models. This review paper also sheds new light on the cardioprotective mechanisms of magnolol and honokiol. However, their cardioprotective potential is limited to animal in vivo models and in vitro models. Only a single study has examined the cardiovascular properties of extract in obese mice. In addition, there is no clinical evidence for the absorption and bioavailability of extracts and their main bioactive compounds in humans. Moreover, there are no studies simultaneously comparing the activity of magnolol and honokiol. Therefore, there is a need for such studies. There are also no recommendations regarding their effective or safe doses for prophylaxis and the treatment of CVDs.
已发现该属植物具有不同的生物学特性，包括抗氧化、抗癌等。例如，它是一种在亚洲各国，尤其是中国、韩国和日本使用的传统经典草药。厚朴树皮是这种植物的主要药用部位。本文综述了关于厚朴树皮及其活性成分，特别是厚朴酚与和厚朴酚的现有知识状态，特别强调了它们在各种模型中的心脏保护活性。这篇综述文章还为厚朴酚与和厚朴酚的心脏保护机制提供了新的见解。然而，它们的心脏保护潜力仅限于动物体内模型和体外模型。仅有一项研究考察了厚朴提取物在肥胖小鼠中的心血管特性。此外，没有临床证据表明厚朴提取物及其主要生物活性化合物在人体中的吸收和生物利用度。而且，没有研究同时比较厚朴酚与和厚朴酚的活性。因此，需要开展此类研究。对于它们预防和治疗心血管疾病的有效或安全剂量也没有相关建议。
