Li Juan, Zheng Xinhua, Qi Jinxu
Department of Pharmacy, School of Medicine, Chongwen Campus, Pingdingshan University, Pingdingshan 467000, China.
Molecules. 2025 Apr 23;30(9):1874. doi: 10.3390/molecules30091874.
Stigmasterol is a plant-derived phytosterol that has attracted considerable attention because of its diverse biological activities and potential therapeutic applications. In this review, the chemical properties, biosynthesis, and biological effects of stigmasterol are exhaustively summarized. Furthermore, the anti-inflammatory, antioxidant, anticancer, neuroprotective, and hypolipidemic activities of stigmasterol have been discussed. Findings from various in vitro and in vivo studies have revealed its potential in treating various diseases, including cancer, diabetes, neurological disorders, and inflammatory conditions. The mechanisms underlying these effects are also discussed, particularly emphasizing the regulation of key signaling pathways and molecular targets, to further clarify the therapeutic role of stigmasterol. This review would provide a reference for further exploring the utility of stigmasterol as a therapeutic agent, thereby contributing to the improvement of human health.
豆甾醇是一种植物源植物甾醇，因其多样的生物活性和潜在的治疗应用而备受关注。在这篇综述中，详尽总结了豆甾醇的化学性质、生物合成及生物学效应。此外，还讨论了豆甾醇的抗炎、抗氧化、抗癌、神经保护和降血脂活性。各种体外和体内研究的结果揭示了其在治疗包括癌症、糖尿病、神经疾病和炎症性疾病在内的多种疾病方面的潜力。还讨论了这些作用的潜在机制，特别强调了关键信号通路和分子靶点的调控，以进一步阐明豆甾醇的治疗作用。这篇综述将为进一步探索豆甾醇作为治疗剂的效用提供参考，从而有助于改善人类健康。
