Wang Shuang, Shen Congcong, Zhang Shengyu, Di Han, Wang Yanhong, Guan Feng
School of Pharmacy, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China.
Key Laboratory of Basic and Application Research of Beiyao, Ministry of Education, Heilongjiang University of Chinese Medicine, 24 Heping Road, Xiangfang District, Harbin 150040, China.
Molecules. 2025 Apr 25;30(9):1922. doi: 10.3390/molecules30091922.
Makino (), a perennial herb in the Violaceae family, is recognized for its violet flowers and has a longstanding role in ethnomedicine for treating various inflammatory diseases, such as boils, furuncles, carbuncles, and both acute and chronic hepatitis, among others. A comprehensive literature review was conducted utilizing resources including the Chinese Pharmacopoeia, Flora of China, Web of Science, PubMed, Baidu Scholar, Google Scholar, and China National Knowledge Infrastructure (CNKI). This paper serves as the inaugural comprehensive review of the latest findings regarding the botany, traditional applications, phytochemistry, pharmacological properties, quality control, and prospective uses of . The objective is to provide a robust foundation for future research and to suggest novel avenues for exploring its potential applications. To date, 162 chemical constituents have been isolated from , with flavonoids and coumarins identified as particularly abundant. These compounds exhibit promising activities, including anti-inflammatory, anti-pyretic, anti-viral, anti-tumor, anti-lung injury, anti-liver injury, anti-bacterial, anti-coagulant, anti-complement, and anti-oxidant properties. Despite considerable advancements in fundamental research on , further investigations are required to elucidate the underlying mechanisms of action and to discover additional uncharacterized compounds. This review underscores the plant's significant development potential, highlighting the necessity for more in-depth exploration.
紫花地丁（Violaceae 科多年生草本植物）以其紫色花朵而闻名，在民族医学中长期用于治疗各种炎症性疾病，如疔疮、疖肿、痈以及急慢性肝炎等。利用《中国药典》《中国植物志》、Web of Science、PubMed、百度学术、谷歌学术和中国知网等资源进行了全面的文献综述。本文首次对紫花地丁在植物学、传统应用、植物化学、药理特性、质量控制和潜在用途等方面的最新研究结果进行了全面综述。目的是为未来的研究提供坚实的基础，并为探索其潜在应用提出新的途径。迄今为止，已从紫花地丁中分离出162种化学成分，其中黄酮类化合物和香豆素类化合物含量尤为丰富。这些化合物具有抗炎、解热、抗病毒、抗肿瘤、抗肺损伤、抗肝损伤、抗菌、抗凝、抗补体和抗氧化等有前景的活性。尽管紫花地丁的基础研究取得了相当大的进展，但仍需要进一步研究以阐明其潜在作用机制，并发现其他未表征的化合物。本综述强调了该植物具有显著的开发潜力，突出了进行更深入探索的必要性。
