Garbuz Olga, Ceban Emil, Istrati Dorin, Railean Nadejda, Toderas Ion, Gulea Aurelian
Laboratory of Systematics and Molecular Phylogenetics, Institute of Zoology, Moldova State University, 1 Academiei Street, MD-2028 Chisinau, Moldova.
Department of Urology and Surgical Nephrology, University of Medicine and Pharmacy "Nicolae Testemitanu", 165 Stefan cel Mare si Sfant Bd., MD-2004 Chisinau, Moldova.
Molecules. 2025 May 7;30(9):2077. doi: 10.3390/molecules30092077.
Thiosemicarbazone-based compounds have attracted significant attention in recent years due to their potential as inhibitors of cancer cell proliferation. They not only exhibit strong antiproliferative effects but also possess antioxidant properties that are crucial in combating oxidative stress linked to cancer progression. This review highlights specific compounds that not only exhibit significantly higher antiproliferative activities but also demonstrate lower toxicity compared to traditional chemotherapy agents. This is important because it suggests that these compounds could provide better treatment options while reducing the side effects often associated with chemotherapy. A detailed analysis of the structure-activity relationships (SARs) reveals that the unique structural features of these compounds play a crucial role in their enhanced effectiveness. Understanding which molecular characteristics contribute to improved activity will be key for future compound design. The findings from this study emphasize the need for further exploration and development of these novel agents. By investigating their biological mechanisms and optimizing their structures, researchers can improve cancer treatment strategies, providing safer and more effective options for patients. Despite substantial previous research on thiosemicarbazones and isothiosemicarbazones, the field still holds many unknowns and opportunities for discovery. Studying coordination chemistry with 3 metal ions and strategically modifying their inner structures may lead to new compounds with promising biological activities and selectivity. Overall, exploring thiosemicarbazones and isothiosemicarbazones as innovative pharmacological agents against cancer could unlock their full potential, significantly enhancing cancer treatment protocols and improving patient survival rates.
近年来，基于硫代氨基脲的化合物因其作为癌细胞增殖抑制剂的潜力而备受关注。它们不仅具有强大的抗增殖作用，还具有抗氧化特性，这对于对抗与癌症进展相关的氧化应激至关重要。本综述重点介绍了一些特定化合物，这些化合物不仅表现出显著更高的抗增殖活性，而且与传统化疗药物相比毒性更低。这一点很重要，因为这表明这些化合物可以提供更好的治疗选择，同时减少通常与化疗相关的副作用。对构效关系（SARs）的详细分析表明，这些化合物独特的结构特征在其增强的有效性中起着关键作用。了解哪些分子特征有助于提高活性将是未来化合物设计的关键。这项研究的结果强调了进一步探索和开发这些新型药物的必要性。通过研究它们的生物学机制并优化其结构，研究人员可以改进癌症治疗策略，为患者提供更安全、更有效的选择。尽管之前对硫代氨基脲和异硫代氨基脲进行了大量研究，但该领域仍存在许多未知和发现机会。研究与3种金属离子的配位化学并战略性地修饰其内部结构可能会产生具有有前景的生物活性和选择性的新化合物。总体而言，探索硫代氨基脲和异硫代氨基脲作为创新的抗癌药物可能会释放它们的全部潜力，显著改进癌症治疗方案并提高患者生存率。
