Papanikolaou Marieta, Paul Julia, Nattkemper Leigh A, Kirsner Robert S, Yosipovitch Gil
Department of Dermatology, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
School of Nursing, Oakland University, Rochester, MI 48309, USA.
J Clin Med. 2025 Apr 22;14(9):2877. doi: 10.3390/jcm14092877.
Itch is a commonly experienced problem by individuals with chronic wounds and greatly compromises their quality of life. Scratching can further hinder the wound healing process. Despite this being a clinically recognized issue, our knowledge of its exact prevalence in chronic wounds of different types and the molecular mechanisms driving it is limited. The multifactorial nature of wound itch makes its characterization particularly challenging. The present review is based on a thorough PubMed search, and it aims to provide an overview of existing evidence on the epidemiology, impact, and pathophysiology of wound itch, along with general recommendations on its management. Importantly, our work highlights the merit of screening chronic wound patients for associated pruritus and incorporating anti-itch measures in mainstream wound care.
瘙痒是慢性伤口患者常经历的问题，严重影响他们的生活质量。搔抓会进一步阻碍伤口愈合过程。尽管这是一个临床公认的问题，但我们对其在不同类型慢性伤口中的确切患病率以及引发瘙痒的分子机制的了解有限。伤口瘙痒的多因素性质使其特征化极具挑战性。本综述基于对PubMed的全面检索，旨在概述有关伤口瘙痒的流行病学、影响和病理生理学的现有证据，以及关于其管理的一般建议。重要的是，我们的工作强调了筛查慢性伤口患者是否存在相关瘙痒并将止痒措施纳入主流伤口护理的价值。
