Şahin Koray, Kaya Hakan Batuhan, Demirkıran Cemil Burak, Ziroğlu Nezih, Koukos Christos, Uçan Vahdet, Kapıcıoğlu Mehmet, Bilsel Kerem
Department of Orthopedics and Traumatology, Bezmialem Vakif University, Istanbul 34093, Turkey.
Department of Orthopedics and Traumatology, Saray State Hospital, Tekirdağ 59600, Turkey.
J Clin Med. 2025 Apr 24;14(9):2926. doi: 10.3390/jcm14092926.
: Reverse shoulder arthroplasty (RSA) has been widely used for the treatment of shoulder pathologies, particularly rotator cuff tear arthropathy. Currently, it is also increasingly performed for different indications. Like in any arthroplasty procedure, periprosthetic joint infection (PJI) is one of the most concerning complications and may have devastating outcomes. This study aimed to identify risk factors for PJI following RSA. : This retrospective case-control study was conducted with patients who underwent RSA during the study period. Based on PJI occurrence during the follow-up period, patients were divided into two groups: Group I (no infection) and Group II (infection). The relationship between numerous clinical variables and PJI was tested. All variables were initially evaluated through univariate analysis between the two groups, and variables showing significant differences between the two study groups were subjected to multivariate logistic regression analysis to determine independent risk factors. : The study included 302 patients, with a mean age of 69.6 ± 10.1 years and a mean follow-up duration of 59.8 ± 24.7 months. During the follow-up period, PJI was not detected in 289 patients (95.7%) (Group I), while 13 patients (4.3%) developed PJI (Group II). Univariate analysis revealed a significant association between preoperative C-reactive protein (CRP) value ( = 0.001) and preoperative diabetes history ( = 0.007) with PJI. Multivariate logistic regression analysis, including these two variables, showed that diabetes was an independent risk factor for PJI development ( = 0.01, odds ratio = 4.85). Preoperative CRP elevation was not observed as an independent risk factor. : This study demonstrated a significant association between high preoperative CRP levels and diabetes with PJI. Additionally, the presence of diabetes was identified as an independent risk factor for infection, with a 4.85-fold higher risk of PJI development in patients with a history of diabetes.
反肩关节置换术（RSA）已被广泛用于治疗肩部疾病，尤其是肩袖撕裂性关节病。目前，它也越来越多地用于不同的适应症。与任何关节置换手术一样，假体周围关节感染（PJI）是最令人担忧的并发症之一，可能会产生毁灭性的后果。本研究旨在确定RSA术后PJI的危险因素。：本回顾性病例对照研究对研究期间接受RSA的患者进行。根据随访期间PJI的发生情况，将患者分为两组：第一组（无感染）和第二组（感染）。测试了众多临床变量与PJI之间的关系。所有变量首先通过两组之间的单因素分析进行评估，在两个研究组之间显示出显著差异的变量进行多因素逻辑回归分析，以确定独立的危险因素。：该研究纳入了302例患者，平均年龄为69.6±10.1岁，平均随访时间为59.8±24.7个月。在随访期间，289例患者（95.7%）未检测到PJI（第一组），而13例患者（4.3%）发生了PJI（第二组）。单因素分析显示术前C反应蛋白（CRP）值（=0.001）和术前糖尿病史（=0.007）与PJI之间存在显著关联。包括这两个变量的多因素逻辑回归分析表明，糖尿病是PJI发生的独立危险因素（=0.01，比值比=4.85）。术前CRP升高未被视为独立危险因素。：本研究表明术前高CRP水平和糖尿病与PJI之间存在显著关联。此外，糖尿病的存在被确定为感染的独立危险因素，有糖尿病史的患者发生PJI的风险高出4.85倍。
