Kotsimpou Stamatia, Liampas Ioannis, Dastamani Metaxia, Marogianni Chrysa, Stamati Polyxeni, Tsika Antonia, Messinis Lampros, Nasios Grigorios, Dardiotis Efthimios, Siokas Vasileios
Department of Neurology, University Hospital of Larissa, Faculty of Medicine, School of Health Sciences, University of Thessaly, 41100 Larissa, Greece.
Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
J Clin Med. 2025 Apr 26;14(9):3001. doi: 10.3390/jcm14093001.
Mild cognitive impairment in Parkinson's disease (PD-MCI) affects approximately 20-50% of patients, and it is associated with an increased risk of dementia. Computer-assisted cognitive interventions (CCTs) have been proposed as a promising method of improving cognitive function in these patients. This review aims to (1) demonstrate the effectiveness of computer-based intervention in PD-MCI, and (2) determine the most effective iteration. A review was performed using PubMed, Google Scholar, and ScienceDirect. Full texts of randomized clinical trials (RCTs) involving CCT intervention in PD-MCI and published in English language journals between 2014 and 2024 were included. Of the 747 studies identified, 6 studies fulfilled the eligibility criterion for this review. Patients receiving CCTs showed significant improvements in global cognition and executive function, while mood was not significantly affected in most studies. CCT improves cognitive functions, particularly memory and executive abilities, but has little effect on mood. Although the results are encouraging, there are potential methodological biases that need to be considered.
帕金森病轻度认知障碍（PD-MCI）影响约20%-50%的患者，且与痴呆风险增加相关。计算机辅助认知干预（CCT）已被提议作为改善这些患者认知功能的一种有前景的方法。本综述旨在（1）证明基于计算机的干预对PD-MCI的有效性，以及（2）确定最有效的干预方式。使用PubMed、谷歌学术和科学Direct进行了一项综述。纳入了2014年至2024年期间发表在英文期刊上的涉及CCT干预PD-MCI的随机临床试验（RCT）的全文。在确定的747项研究中，6项研究符合本综述的纳入标准。接受CCT的患者在整体认知和执行功能方面有显著改善，而在大多数研究中情绪未受到显著影响。CCT可改善认知功能，尤其是记忆和执行能力，但对情绪影响不大。尽管结果令人鼓舞，但仍存在一些潜在的方法学偏倚需要考虑。
