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机器人辅助胸腔镜手术与电视辅助胸腔镜手术:哪种是早期非小细胞肺癌的首选手术方式?

Robotic-Assisted Thoracoscopic Surgery Versus Video-Assisted Thoracoscopic Surgery: Which Is the Preferred Approach for Early-Stage NSCLC?

作者信息

Syrigos Nikolaos, Fyta Eleni, Goumas Georgios, Trontzas Ioannis P, Vathiotis Ioannis, Panagiotou Emmanouil, Nikiteas Nikolaos I, Kotteas Elias, Dimitroulis Dimitrios

机构信息

Hellenic Minimally Invasive and Robotic Surgery (MIRS) Study Group, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

3rd Department of Internal Medicine, Oncology Unit, "SOTIRIA" General Hospital of Chest Diseases, National and Kapodistrian University of Athens, 11527 Athens, Greece.

出版信息

J Clin Med. 2025 Apr 28;14(9):3032. doi: 10.3390/jcm14093032.

Abstract

Lung cancer is the leading cause of cancer-related mortality among both men and women worldwide, underscoring the need for an effective treatment strategy. For early-stage non-small cell lung cancer [NSCLC], surgical resection is the standard treatment. Robotic-assisted thoracic surgery [RATS] and video-assisted thoracic surgery [VATS] are better than open thoracotomy because they are less invasive. Recent lung cancer screening programs are detecting NSCLC at earlier stages, which is expected to result in an increase in the number of NSCLC surgeries as early-stage cases are diagnosed. A limited number of randomized controlled trials have compared RATS and VATS in operable NSCLC. We conducted a literature review to summarize the available evidence on these two surgical techniques. The purpose of this study is to compare the intraoperative and postoperative outcomes of RATS and VATS in early-stage NSCLC patients. RATS shows lower conversion rates to thoracotomy (6.3% vs. 13.1% < 0.01) and more thorough lymph node dissection than VATS (e.g., 7.5 vs. 5.6 stations, < 0.001). However, RATS is linked to considerably higher costs (USD 22,582 vs. USD 17,874, < 0.05) and longer operative times (median 241.7 vs. 214.4 min, = 0.06). The two techniques exhibited minimal differences in postoperative complications and pain, while RATS patients experienced shortened hospital stays (4-5 vs. 5-6 days, < 0.006). While the accuracy of staging and treatment planning is improved by the improved lymph node retrieval in RATS, the long-term survival rate is still uncertain.

摘要

肺癌是全球男性和女性癌症相关死亡的主要原因,这凸显了有效治疗策略的必要性。对于早期非小细胞肺癌(NSCLC),手术切除是标准治疗方法。机器人辅助胸外科手术(RATS)和电视辅助胸外科手术(VATS)比开胸手术更好,因为它们的侵入性较小。最近的肺癌筛查项目在更早阶段检测到NSCLC,随着早期病例被诊断出来,预计NSCLC手术数量将会增加。有限数量的随机对照试验比较了可手术NSCLC患者的RATS和VATS。我们进行了一项文献综述,以总结关于这两种手术技术的现有证据。本研究的目的是比较早期NSCLC患者中RATS和VATS的术中和术后结果。RATS的开胸手术转化率较低(6.3%对13.1%,<0.01),并且与VATS相比,淋巴结清扫更彻底(例如,7.5个对5.6个淋巴结站,<0.001)。然而,RATS的成本要高得多(22,582美元对17,874美元,<0.05),手术时间也更长(中位数241.7分钟对214.4分钟,=0.06)。这两种技术在术后并发症和疼痛方面表现出极小的差异,而RATS患者的住院时间缩短(4 - 5天对5 - 6天,<0.006)。虽然RATS中淋巴结清扫的改善提高了分期和治疗计划的准确性,但长期生存率仍然不确定。

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