Zeleke Amanuel, Bizuayehu Tilahun, Solela Gashaw, Teju Sebhatleab, Gebreamlak Tesfamariam, Adamu Abraham, Amogne Wondwossen
Department of Internal Medicine Yekatit 12 Hospital Medical College Addis Ababa Ethiopia.
Infectious Diseases Unit, Department of Internal Medicine College of Health Sciences Addis Ababa Ethiopia.
Clin Case Rep. 2025 May 13;13(5):e70493. doi: 10.1002/ccr3.70493. eCollection 2025 May.
Tuberculosis rarely affects the breast. This report presents a case of a microbiologically confirmed primary tubercular breast abscess in a young Ethiopian woman. A 26-year-old woman presented with left breast swelling and pain for 1 year. She was initially suspected to have a pyogenic abscess of the breast and was treated with unspecified oral antibiotics but had no clinical response. In addition, surgical drainage was done, followed by a 4-week course of oral amoxicillin-clavulanic acid. However, the swelling gradually increased in size and formed a sinus tract with a purulent discharge. Subsequently, breast tuberculosis was suspected, and a GeneXpert from the discharge was performed, which revealed rifampicin-sensitive . She was started on anti-tuberculous medications and showed significant clinical response after 6 months of therapy. Breast tuberculosis should be considered earlier in patients with breast lesions in the absence of an alternative diagnosis and/or if the response to antibiotics is not as expected. In this case, histopathology from the breast lesion and cartridge-based nucleic acid amplification test (GeneXpert) from the breast discharge were confirmatory for breast tuberculosis.
结核病很少累及乳腺。本报告介绍了一例经微生物学确诊的年轻埃塞俄比亚女性原发性结核性乳腺脓肿病例。一名26岁女性因左乳肿胀和疼痛1年就诊。她最初被怀疑患有乳腺化脓性脓肿，并接受了未指明的口服抗生素治疗，但无临床反应。此外，进行了手术引流，随后口服阿莫西林-克拉维酸4周。然而，肿胀逐渐增大并形成了一个有脓性分泌物的窦道。随后，怀疑为乳腺结核，对分泌物进行了Xpert MTB/RIF检测，结果显示对利福平敏感。她开始接受抗结核药物治疗，治疗6个月后临床反应显著。对于乳腺病变患者，在没有其他诊断和/或对抗生素治疗反应不佳的情况下，应尽早考虑乳腺结核。在本病例中，乳腺病变的组织病理学检查以及乳腺分泌物的基于 cartridge 的核酸扩增试验（Xpert MTB/RIF）确诊为乳腺结核。
