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局部晚期直肠癌的全新辅助治疗

Total neoadjuvant therapy for locally advanced rectal cancer.

作者信息

Mueller Sophie, Kao Yung-Shuo, Kastner Carolin, Chen Po-Huang, Hendricks Anne, Lee Gin Yi, Koehler Franziska, Jhou Hong-Jie, Germer Christoph-Thomas, Kang Enoch Yi-No, Janka Heidrun, Ho Ching-Liang, Lee Cho-Hao, Wiegering Armin

机构信息

Department of General, Visceral, Transplant, Vascular and Paediatric Surgery, University Hospital Wuerzburg, Wuerzburg, Germany.

Department of Radiation Oncology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan.

出版信息

Cochrane Database Syst Rev. 2025 May 14;5(5):CD015590. doi: 10.1002/14651858.CD015590.

DOI:10.1002/14651858.CD015590
PMID:40365860
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12076550/
Abstract

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effectiveness and safety of total neoadjuvant therapy versus standard therapy in individuals with locally advanced rectal cancer.

摘要

这是一项Cochrane系统评价（干预措施）的方案。目标如下：评估全新辅助治疗与标准治疗对局部晚期直肠癌患者的有效性和安全性。

相似文献

1
Total neoadjuvant therapy for locally advanced rectal cancer.局部晚期直肠癌的全新辅助治疗
Cochrane Database Syst Rev. 2025 May 14;5(5):CD015590. doi: 10.1002/14651858.CD015590.
2
In favor of total neoadjuvant therapy (TNT) for locally advanced rectal carcinoma.支持局部晚期直肠癌的全新辅助治疗（TNT）。
Clin Transl Oncol. 2020 May;22(5):793-794. doi: 10.1007/s12094-019-02177-w. Epub 2019 Jul 15.
3
Is Total Neoadjuvant Treatment Beneficial for Locally Advanced Rectal Cancer? A Meta-Analysis of Randomized Controlled Trials.全新辅助治疗对局部进展期直肠癌有益吗？一项随机对照试验的荟萃分析。
Oncology. 2024;102(5):399-413. doi: 10.1159/000534815. Epub 2023 Nov 3.
4
Total Neoadjuvant Therapy vs Standard Therapy in Locally Advanced Rectal Cancer: A Systematic Review and Meta-analysis.局部晚期直肠癌的新辅助治疗与标准治疗的比较：系统评价和荟萃分析。
JAMA Netw Open. 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097.
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Preoperative short-course radiotherapy followed by chemotherapy and PD-1 inhibitor administration for locally advanced rectal cancer: A study protocol of a randomized phase II/III trial (STELLAR II study).术前短程放疗联合化疗和 PD-1 抑制剂治疗局部进展期直肠癌：一项随机 II/III 期试验（STELLAR II 研究）的研究方案。
Colorectal Dis. 2024 Sep;26(9):1732-1740. doi: 10.1111/codi.17090. Epub 2024 Jul 17.
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Comment on: Total neoadjuvant therapy versus standard neoadjuvant treatment strategies for the management of locally advanced rectal cancer: network meta-analysis of randomized clinical trials.评论：局部晚期直肠癌治疗中全新辅助治疗与标准新辅助治疗策略的比较：随机临床试验的网状Meta分析
Br J Surg. 2024 Aug 2;111(8). doi: 10.1093/bjs/znae209.
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[Efficacy and safety of total neoadjuvant therapy versus neoadjuvant chemoradiotherapy in the treatment of locally advanced rectal cancer: a meta-analysis].全新辅助治疗与新辅助放化疗治疗局部晚期直肠癌的疗效和安全性：一项荟萃分析
Zhonghua Wei Chang Wai Ke Za Zhi. 2022 Jun 25;25(6):531-538. doi: 10.3760/cma.j.cn441530-20210806-00311.
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Evaluating the Impact of Induction and Consolidation Total Neoadjuvant Therapies Compared to Conventional Chemoradiotherapy for Locally Advanced Rectal Cancer: A Systematic Review and Network Meta-analysis.评估诱导和巩固性全新辅助治疗与传统放化疗相比对局部晚期直肠癌的影响：一项系统评价和网状Meta分析
Dis Colon Rectum. 2025 Jun 1;68(6):687-701. doi: 10.1097/DCR.0000000000003687. Epub 2025 Mar 10.
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Comparison of the efficacy of neoadjuvant chemotherapy and neoadjuvant chemoradiotherapy in locally advanced rectal cancer patients: meta-analysis of randomized controlled trials.局部晚期直肠癌患者新辅助化疗与新辅助放化疗疗效比较：随机对照试验的荟萃分析
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Korean Society of Coloproctology (KSCP) trial of cONsolidation Chemotherapy for Locally advanced mid or low rectal cancer after neoadjUvant concurrent chemoraDiothErapy: a multicenter, randomized controlled trial (KONCLUDE).韩国结直肠外科学会（KSCP）新辅助同期放化疗后局部中低位进展期直肠癌巩固化疗的临床试验：一项多中心、随机对照试验（KONCLUDE）。
BMC Cancer. 2018 May 8;18(1):538. doi: 10.1186/s12885-018-4466-7.

本文引用的文献

1
NCCN Guidelines® Insights: Rectal Cancer, Version 3.2024.NCCN 指南®洞察：直肠癌，第 3.2024 版。
J Natl Compr Canc Netw. 2024 Aug;22(6):366-375. doi: 10.6004/jnccn.2024.0041.
2
Total neoadjuvant therapy with mFOLFIRINOX versus preoperative chemoradiotherapy in patients with locally advanced rectal cancer: long-term results of the UNICANCER-PRODIGE 23 trial.mFOLFIRINOX 新辅助治疗与术前放化疗对比局部进展期直肠癌的疗效：UNICANCER-PRODIGE 23 临床试验的长期结果。
Ann Oncol. 2024 Oct;35(10):873-881. doi: 10.1016/j.annonc.2024.06.019. Epub 2024 Jul 8.
3
Evolving Standards of Care in the Management of Localized Colorectal Cancer.局部结直肠癌治疗中照护标准的演变。
Am Soc Clin Oncol Educ Book. 2024 Jun;44(3):e432034. doi: 10.1200/EDBK_432034.
4
Oncological outcomes after a pathological complete response following total neoadjuvant therapy or chemoradiotherapy for high-risk locally advanced rectal cancer in the RAPIDO trial.RAPIDO 试验中全新辅助治疗或放化疗后病理完全缓解的高危局部进展期直肠癌的肿瘤学结局。
Eur J Cancer. 2024 Jun;204:114044. doi: 10.1016/j.ejca.2024.114044. Epub 2024 Apr 7.
5
Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial.总新辅助治疗直肠腺癌患者的器官保存的长期结果：随机 II 期 OPRA 试验。
J Clin Oncol. 2024 Feb 10;42(5):500-506. doi: 10.1200/JCO.23.01208. Epub 2023 Oct 26.
6
Surgical and short-term oncological safety of total neoadjuvant therapy in high-risk locally advanced rectal cancer.全新辅助治疗高危局部进展期直肠癌的手术和短期肿瘤学安全性。
ANZ J Surg. 2024 Feb;94(1-2):175-180. doi: 10.1111/ans.18739. Epub 2023 Oct 17.
7
Total neoadjuvant therapy for rectal cancer: a guide for surgeons.直肠癌的新辅助治疗：外科医生指南。
Can J Surg. 2023 Apr 21;66(2):E196-E201. doi: 10.1503/cjs.005822. Print 2023 Mar-Apr.
8
Neoadjuvant Short-Course Radiotherapy Followed by Consolidation Chemotherapy before Surgery for Treating Locally Advanced Rectal Cancer: A Systematic Review and Meta-Analysis.新辅助短程放疗联合巩固化疗序贯手术治疗局部进展期直肠癌的系统评价和荟萃分析。
Curr Oncol. 2022 May 19;29(5):3708-3727. doi: 10.3390/curroncol29050297.
9
Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy.直肠癌患者接受全新辅助治疗后的器官保存。
J Clin Oncol. 2022 Aug 10;40(23):2546-2556. doi: 10.1200/JCO.22.00032. Epub 2022 Apr 28.
10
The importance of MRI for rectal cancer evaluation.MRI 在直肠癌评估中的重要性。
Surg Oncol. 2022 Aug;43:101739. doi: 10.1016/j.suronc.2022.101739. Epub 2022 Mar 18.