Mugada Vinodkumar, Allada Satya Sai Srinivas, Rvs Koppala Chaitanya, Yarguntla Srinivasa Rao
Vignan Institute of Pharmaceutical Technology, Department of Pharmacy Practice, Duvvada, India.
Vignan Institute of Pharmaceutical Technology, Department of Pharmacology, Duvvada, India.
Turk J Pharm Sci. 2025 May 14;22(2):83-90. doi: 10.4274/tjps.galenos.2025.44902.
The multidisciplinary team approach improves adverse drug reaction (ADR) reporting and management. Our study aims to integrate a pharmacovigilance (PV) and Response Team within the general medicine department to improve ADR reporting and management.
We conducted a prospective cross-sectional study for seven months in four general medicine wards. We proposed a PV and response unit team (PRUT), comprising a nursing student, and a Doctor of Pharmacy (intern). After the team received interventional educational training, we integrated them with the physician and head nurse of each general medicine inpatient ward. We then evaluated the effectiveness of the team in ADR reporting and management using a feedback survey.
In this study, comorbidities (30.69%) and polypharmacy (≥5 drugs) (26.25%) were major predisposing factors. Among drug-related problems in 125 patients, inappropriate drug use (28.80%) and unclear dose timing (21.60%) were predominant. Gastrointestinal disorders were common (44.73%), with dose adjustment being the top management strategy (36.84%). Over 71% supported the PRUT for improving patient safety and reducing medication errors, noting high effectiveness in consultation (85.92%) and in reducing the ADR reporting burden (87.32%). There is a statistically significant association between the level of agreement on the effectiveness of PRUT among healthcare professionals (p<0.01). Most healthcare professionals agreed on PRUT's effectiveness without any reports of low agreement levels.
The PRUT effectively reported and managed ADRs. A multidisciplinary approach improves ADR reporting and management.
多学科团队方法可改善药物不良反应（ADR）报告与管理。我们的研究旨在将药物警戒（PV）和反应团队整合到普通内科，以改善ADR报告与管理。
我们在四个普通内科病房进行了为期七个月的前瞻性横断面研究。我们组建了一个PV和反应单元团队（PRUT），由一名护理专业学生和一名药学博士（实习生）组成。在该团队接受干预性教育培训后，我们将他们与每个普通内科住院病房的医生和护士长整合在一起。然后，我们通过反馈调查评估该团队在ADR报告与管理方面的有效性。
在本研究中，合并症（30.69%）和多重用药（≥5种药物）（26.25%）是主要的诱发因素。在125例患者的药物相关问题中，用药不当（28.80%）和剂量时间不明确（21.60%）最为常见。胃肠道疾病很常见（44.73%），剂量调整是首要的管理策略（36.84%）。超过71%的人支持PRUT改善患者安全和减少用药错误，指出其在会诊方面（85.92%）和减轻ADR报告负担方面（87.32%）有效性很高。医疗保健专业人员对PRUT有效性的认同程度之间存在统计学显著关联（p<0.01）。大多数医疗保健专业人员认同PRUT的有效性，没有任何低认同度的报告。
PRUT有效报告和管理了ADR。多学科方法改善了ADR报告与管理。
